AIMC Topic: Deep Learning

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Application of a deep-learning marker for morbidity and mortality prediction derived from retinal photographs: a cohort development and validation study.

The lancet. Healthy longevity
BACKGROUND: Biological ageing markers are useful to risk stratify morbidity and mortality more precisely than chronological age. In this study, we aimed to develop a novel deep-learning-based biological ageing marker (referred to as RetiPhenoAge here...

Deep Learning Virtual Contrast-Enhanced T1 Mapping for Contrast-Free Myocardial Extracellular Volume Assessment.

Journal of the American Heart Association
BACKGROUND: The acquisition of contrast-enhanced T1 maps to calculate extracellular volume (ECV) requires contrast agent administration and is time consuming. This study investigates generative adversarial networks for contrast-free, virtual extracel...

Enhancing pap smear image classification: integrating transfer learning and attention mechanisms for improved detection of cervical abnormalities.

Biomedical physics & engineering express
Cervical cancer remains a major global health challenge, accounting for significant morbidity and mortality among women. Early detection through screening, such as Pap smear tests, is crucial for effective treatment and improved patient outcomes. How...

Personalized prediction of immunotherapy response in lung cancer patients using advanced radiomics and deep learning.

Cancer imaging : the official publication of the International Cancer Imaging Society
BACKGROUND: Lung cancer (LC) is a leading cause of cancer-related mortality, and immunotherapy (IO) has shown promise in treating advanced-stage LC. However, identifying patients likely to benefit from IO and monitoring treatment response remains cha...

Predicting RNA sequence-structure likelihood via structure-aware deep learning.

BMC bioinformatics
BACKGROUND: The active functionalities of RNA are recognized to be heavily dependent on the structure and sequence. Therefore, a model that can accurately evaluate a design by giving RNA sequence-structure pairs would be a valuable tool for many rese...

Sex estimation using skull silhouette images from postmortem computed tomography by deep learning.

Scientific reports
Prompt personal identification is required during disasters that can result in many casualties. To rapidly estimate sex based on skull structure, this study applied deep learning using two-dimensional silhouette images, obtained from head postmortem ...

Deep learning for discriminating non-trivial conformational changes in molecular dynamics simulations of SARS-CoV-2 spike-ACE2.

Scientific reports
Molecular dynamics (MD) simulations produce a substantial volume of high-dimensional data, and traditional methods for analyzing these data pose significant computational demands. Advances in MD simulation analysis combined with deep learning-based a...

Managing spatio-temporal heterogeneity of susceptibles by embedding it into an homogeneous model: A mechanistic and deep learning study.

PLoS computational biology
Accurate prediction of epidemics is pivotal for making well-informed decisions for the control of infectious diseases, but addressing heterogeneity in the system poses a challenge. In this study, we propose a novel modelling framework integrating the...

Exploring the potential of structure-based deep learning approaches for T cell receptor design.

PLoS computational biology
Deep learning methods, trained on the increasing set of available protein 3D structures and sequences, have substantially impacted the protein modeling and design field. These advancements have facilitated the creation of novel proteins, or the optim...

Prompt-guided and multimodal landscape scenicness assessments with vision-language models.

PloS one
Recent advances in deep learning and Vision-Language Models (VLM) have enabled efficient transfer to downstream tasks even when limited labelled training data is available, as well as for text to be directly compared to image content. These propertie...