AIMC Topic: Disease Models, Animal

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Integrating artificial intelligence and optogenetics for Parkinson's disease diagnosis and therapeutics in male mice.

Nature communications Aug 21, 2025
Parkinson's disease (PD), a progressive neurodegenerative disorder, presents complex motor symptoms and lacks effective disease-modifying treatments. Here we show that integrating artificial intelligence (AI) with optogenetic intervention, termed opt...
Behavior, Animal Mice, Transgenic Optogenetics Artificial Intelligence Animals Male Mice Disease Models, Animal Mice, Inbred C57BL Parkinson Disease Gait Humans
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Balancing ethics and statistics: machine learning facilitates highly accurate classification of mice according to their trait anxiety with reduced sample sizes.

Translational psychiatry Aug 21, 2025
Understanding how individual differences influence vulnerability to disease and responses to pharmacological treatments represents one of the main challenges in behavioral neuroscience. Nevertheless, inter-individual variability and sex-specific patt...
Machine Learning Female Animals Male Sample Size Supervised Machine Learning Behavior, Animal Endophenotypes Anxiety Mice Disease Models, Animal Mice, Inbred C57BL
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Comprehensive multi-omics analysis reveals the core role of glycerophospholipid metabolism in the influence of short-chain fatty acids on the development of sepsis.

Scientific reports Aug 9, 2025
Sepsis is a systemic inflammatory response syndrome caused by infection, which has a high morbidity and mortality. Short-chain fatty acids (SCFAs) have been proved to improve the outcome of sepsis by regulating immunity and metabolism, but its specif...
Transcriptome Sepsis Mice Multiomics Humans Animals Male Gene Expression Profiling Mendelian Randomization Analysis Disease Models, Animal Fatty Acids, Volatile Mice, Inbred C57BL Glycerophospholipids Metabolomics
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Bioinformatics analysis of Rho-signal transduction genes in postmenopausal osteoporosis and periodontitis.

Scientific reports Aug 5, 2025
Postmenopausal osteoporosis (PMOP) increases the risk of periodontitis (PD), yet the shared mechanisms remain unclear. Rho-signal transduction genes may play a role due to their involvement in bone remodeling. This study aimed to explore Rho-related ...
RNA, Long Noncoding Periodontitis Osteoporosis, Postmenopausal c-Mer Tyrosine Kinase Computational Biology Signal Transduction Disease Models, Animal Humans Biomarkers Female Animals Gene Expression Profiling Gene Regulatory Networks Mice
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Subsecond Analysis of Locomotor Activity in Parkinsonian Mice.

eNeuro Aug 5, 2025
The degeneration of midbrain dopamine (DA) neurons disrupts the neural control of natural behavior, such as walking, posture, and gait in Parkinson's disease. While some aspects of motor symptoms can be managed by DA replacement therapies, others res...
Animals Male Mice Disease Models, Animal Mice, Inbred C57BL Levodopa Dopaminergic Neurons Parkinsonian Disorders Locomotion Antiparkinson Agents
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NAFLD progression in metabolic syndrome: a Raman spectroscopy and machine learning approach in an animal model.

The Analyst Aug 4, 2025
Nonalcoholic fatty liver disease (NAFLD) is emerging as the leading cause of chronic liver disease in many regions, particularly in association with the rising prevalence of Metabolic syndrome (MetS), affecting more than 30% of the population worldwi...
Male Principal Component Analysis Disease Progression Non-alcoholic Fatty Liver Disease Rats Machine Learning Support Vector Machine Spectrum Analysis, Raman Animals Disease Models, Animal Metabolic Syndrome Liver
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High-Resolution Ultrasound Data for AI-Based Segmentation in Mouse Brain Tumor.

Scientific data Jul 30, 2025
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, making effective treatments essential to improve patient survival. To advance the understanding of GBM and develop more effective therapies, preclinical studies commonly use m...
Ultrasonography Mice Disease Models, Animal Glioblastoma Artificial Intelligence Brain Neoplasms Animals
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CPN2 alleviates cryptorchidism by inhibiting the NF-κB pathway and regulating immune responses.

Autoimmunity Jul 28, 2025
Cryptorchidism, a common male reproductive disorder characterized by undescended testes, is associated with infertility and increased cancer risk. While its etiology remains incompletely understood, accumulating evidence suggests that immune-inflamma...
Male Rats Signal Transduction Testis Disease Models, Animal Humans NF-kappa B Animals Cryptorchidism Dibutyl Phthalate
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Infant rat ultrasonic vocalizations in the neurodevelopmental model of schizophrenia.

Scientific reports Jul 28, 2025
Schizophrenia is characterized by early brain developmental abnormalities resulting in, among others, compromised communication. Rodent models, such as prenatal exposure to methylazoxymethanol acetate (MAM), help investigate schizophrenia-related def...
Vocalization, Animal Methylazoxymethanol Acetate Disease Models, Animal Schizophrenia Animals, Newborn Prenatal Exposure Delayed Effects Animals Male Rats Pregnancy Female
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Shared pathogenic mechanisms linking obesity and idiopathic pulmonary fibrosis revealed by bioinformatics and in vivo validation.

Scientific reports Jul 17, 2025
Previous studies have suggested a potential correlation between obesity and idiopathic pulmonary fibrosis (IPF). This study aimed to elucidate pathogenic pathways connecting obesity and IPF and identify diagnostic biomarkers for obesity-related pulmo...
Diet, High-Fat Gene Regulatory Networks Disease Models, Animal Male Mice Humans Idiopathic Pulmonary Fibrosis Molecular Docking Simulation Computational Biology Machine Learning Mice, Inbred C57BL Gene Expression Profiling Animals Protein Interaction Maps Obesity
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