AIMC Topic: Disease Models, Animal
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DETECTION OF HYPOVOLEMIA BY THE HYPOTENSION PREDICTION INDEX IS ASSOCIATED WITH GASTROINTESTINAL MICROCIRCULATION DYSFUNCTION IN A PORCINE MODEL OF HEMORRHAGE.
Shock (Augusta, Ga.)
Jul 1, 2025
Background: Postoperative gastrointestinal (GI) dysfunction is a common complication following critical illness. The splanchnic circulation is sensitive to changes in volume status and is unduly impacted by volume loss compared to other organ systems...
Hugan Tiaoshen Formula Improves the Comorbid Mechanism of Schizophrenia and Sleep Disorder via Multitarget Interaction Network.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jun 30, 2025
This study aims to integrate cross-disease omics data and perform multidimensional analysis to uncover the molecular basis of schizophrenia (SCZ) and sleep disorder (SD) comorbidity and to systematically analyze the potential mechanism of the Hugan T...
AI Quantification of Vascular Lesions in Mouse Fundus Fluorescein Angiography.
Translational vision science & technology
Jun 2, 2025
PURPOSE: Quantifying vascular leakage in fundus fluorescein angiography (FFA) is a critical endpoint in preclinical models of diseases such as neovascular age-related macular degeneration, retinopathy of prematurity, and diabetic retinopathy. Traditi...
Model Systems of Chronic Kidney Disease: A Detailed Overview and Recent Advances.
Journal of biochemical and molecular toxicology
Jun 1, 2025
Experimental model systems, especially animal models, are indispensable tools to study human diseases and to develop new therapeutics. Chronic kidney disease (CKD) is a major global health problem having significantly higher rate of morbidity and mor...
Using deep-learning based segmentation to enable spatial evaluation of knee osteoarthritis (SEKO) in rodent models.
Osteoarthritis and cartilage
Jun 1, 2025
OBJECTIVE: In preclinical models of osteoarthritis (OA), histology is commonly used to evaluate joint remodeling. The current study introduces a deep learning driven histological analysis pipeline for the spatial evaluation of knee osteoarthritis (SE...
Deep learning-driven automated mitochondrial segmentation for analysis of complex transmission electron microscopy images.
Scientific reports
May 30, 2025
Mitochondria are central to cellular energy production and regulation, with their morphology tightly linked to functional performance. Precise analysis of mitochondrial ultrastructure is crucial for understanding cellular bioenergetics and pathology....
Hippocampal-prefrontal functional neural networks in a rat model of fragile X syndrome are poorly organized with limited resiliency.
Scientific reports
May 8, 2025
Fragile X Syndrome (FXS) is a common cause of autism spectrum symptoms. The genetic mutation results in multiple molecular alterations that are hypothesized to negatively impact neural circuit development although the nature of any functional neural ...
Machine Learning Models Based on Stretched-Exponential Diffusion Weighted Imaging to Predict TROP2 Expression in Nude Mouse Breast Cancer Models.
Discovery medicine
Mar 1, 2025
BACKGROUND: Trophoblast cell surface antigen 2 (TROP2) is a promising target for various cancers, including breast cancer. The development of noninvasive techniques for assessing TROP2 expression in tumors holds considerable importance. This study ai...
RetOCTNet: Deep Learning-Based Segmentation of OCT Images Following Retinal Ganglion Cell Injury.
Translational vision science & technology
Feb 3, 2025
PURPOSE: We present RetOCTNet, a deep learning tool to segment the retinal nerve fiber layer (RNFL) and total retinal thickness automatically from optical coherence tomography (OCT) scans in rats following retinal ganglion cell (RGC) injury.
Post-Transplant Liver Monitoring Utilizing Integrated Surface-Enhanced Raman and AI in Hepatic Ischemia-Reperfusion Injury Animal Model.
International journal of nanomedicine
Jan 1, 2025
BACKGROUND: While liver transplantation saves lives from irreversible liver damage, it poses challenges such as graft dysfunction due to factors like ischemia-reperfusion (IR) injury, which can lead to significant cellular damage and systemic complic...
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