AIMC Topic: Disease Models, Animal

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An Explainable Graph Neural Framework to Identify Cancer-Associated Intratumoral Microbial Communities.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Sep 3, 2024
Microbes are extensively present among various cancer tissues and play critical roles in carcinogenesis and treatment responses. However, the underlying relationships between intratumoral microbes and tumors remain poorly understood. Here, a MIcrobia...
Humans Neoplasms Mice Disease Models, Animal Microbiota Neural Networks, Computer Reproducibility of Results Animals
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Advanced rehabilitation in ischaemic stroke research.

Stroke and vascular neurology Aug 27, 2024
At present, due to the rapid progress of treatment technology in the acute phase of ischaemic stroke, the mortality of patients has been greatly reduced but the number of disabled survivors is increasing, and most of them are elderly patients. Physic...
Brain-Computer Interfaces Physical Therapy Modalities Stroke Rehabilitation Recovery of Function Robotics Ischemic Stroke Treatment Outcome Humans Disease Models, Animal Animals
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Dynamic changes in pyroptosis following spinal cord injury and the identification of crucial molecular signatures through machine learning and single-cell sequencing.

Journal of pharmaceutical and biomedical analysis Aug 26, 2024
The pathological cascade of spinal cord injury (SCI) is highly intricate. The onset of neuroinflammation can exacerbate the extent of damage. Pyroptosis is a form of inflammation-linked programmed cell death (PCD), the inhibition of pyroptosis can pa...
Mice, Inbred C57BL Cell Line Neuroinflammatory Diseases Single-Cell Analysis Machine Learning Microglia Mice Spinal Cord Animals Pyroptosis Disease Models, Animal Spinal Cord Injuries Male
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Machine learning based identification potential feature genes for prediction of drug efficacy in nonalcoholic steatohepatitis animal model.

Lipids in health and disease Aug 24, 2024
BACKGROUND: Nonalcoholic Steatohepatitis (NASH) results from complex liver conditions involving metabolic, inflammatory, and fibrogenic processes. Despite its burden, there has been a lack of any approved food-and-drug administration therapy up till ...
Male Rats Machine Learning Disease Models, Animal Biomarkers MicroRNAs Animals Liver Non-alcoholic Fatty Liver Disease YAP-Signaling Proteins
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Imitating the respiratory activity of the brain stem by using artificial neural networks: exploratory study on an animal model of lactic acidosis and proof of concept.

Journal of clinical monitoring and computing Aug 20, 2024
Artificial neural networks (ANNs) are versatile tools capable of learning without prior knowledge. This study aims to evaluate whether ANN can calculate minute volume during spontaneous breathing after being trained using data from an animal model of...
Neural Networks, Computer Acidosis, Lactic Algorithms Body Temperature Brain Stem Disease Models, Animal Respiration Hydrogen-Ion Concentration Animals Proof of Concept Study Swine Carbon Dioxide Blood Gas Analysis Linear Models Lactic Acid
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Machine learning model for non-alcoholic steatohepatitis diagnosis based on ultrasound radiomics.

BMC medical imaging Aug 20, 2024
BACKGROUND: Non-Alcoholic Steatohepatitis (NASH) is a crucial stage in the progression of Non-Alcoholic Fatty Liver Disease(NAFLD). The purpose of this study is to explore the clinical value of ultrasound features and radiological analysis in predict...
Elasticity Imaging Techniques Rats Rats, Sprague-Dawley Disease Models, Animal Non-alcoholic Fatty Liver Disease Male Ultrasonography ROC Curve Machine Learning Radiomics Algorithms Animals
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Mechanisms of QingRe HuoXue Formula in atherosclerosis Treatment: An integrated approach using Bioinformatics, Machine Learning, and experimental validation.

International immunopharmacology Aug 12, 2024
BACKGROUND: Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease. QingRe HuoXue Formula (QRHXF), a common prescription of traditional Chinese medicine, has a definite effect on the cli...
Plaque, Atherosclerotic Collagen Type I Collagen Type I, alpha 1 Chain Mice, Inbred C57BL Drugs, Chinese Herbal Atherosclerosis Animals Male Molecular Docking Simulation Computational Biology Disease Models, Animal Gene Expression Profiling Mice Humans Machine Learning
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Development of artificial intelligence-driven biosignal-sensitive cardiopulmonary resuscitation robot.

Resuscitation Aug 8, 2024
AIM OF THE STUDY: We evaluated whether an artificial intelligence (AI)-driven robot cardiopulmonary resuscitation (CPR) could improve hemodynamic parameters and clinical outcomes.
Artificial Intelligence Disease Models, Animal Robotics Carotid Arteries Cardiopulmonary Resuscitation Animals Swine Hemodynamics Heart Arrest Ventricular Fibrillation
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Optimizing post-transplantation outcomes: the role of multi-omics, artificial intelligence, and animal models in addressing immunosuppression-associated hepatotoxicity.

International journal of surgery (London, England) Aug 1, 2024
Liver Transplantation Chemical and Drug Induced Liver Injury Disease Models, Animal Humans Immunosuppressive Agents Postoperative Complications Immunosuppression Therapy Multiomics Artificial Intelligence Animals
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Machine learning approaches for influenza A virus risk assessment identifies predictive correlates using ferret model in vivo data.

Communications biology Aug 1, 2024
In vivo assessments of influenza A virus (IAV) pathogenicity and transmissibility in ferrets represent a crucial component of many pandemic risk assessment rubrics, but few systematic efforts to identify which data from in vivo experimentation are mo...
Disease Models, Animal Ferrets Orthomyxoviridae Infections Algorithms Risk Assessment Machine Learning Animals Influenza A virus
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