Alzheimer's & dementia : the journal of the Alzheimer's Association
Sep 13, 2020
INTRODUCTION: Relationships between brain atrophy patterns of typical aging and Alzheimer's disease (AD), white matter disease, cognition, and AD neuropathology were investigated via machine learning in a large harmonized magnetic resonance imaging d...
PURPOSE: Current prediction models for advanced age-related macular degeneration (AMD) are based on a restrictive set of risk factors. The objective of this study was to develop a comprehensive prediction model applying a machine learning algorithm a...
Annals of clinical and translational neurology
Aug 30, 2020
OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease which leads to progressive muscle weakness and eventually death. The increasing availability of large ALS clinical trial datasets have generated much interest in developing...
The Journal of asthma : official journal of the Association for the Care of Asthma
Aug 14, 2020
OBJECTIVE: Acute exacerbations contribute significantly to the morbidity of asthma. Recent studies have shown that early detection and treatment of asthma exacerbations leads to improved outcomes. We aimed to develop a machine learning algorithm to d...
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Aug 14, 2020
OBJECTIVE: Efficient prediction of the progression of mild cognitive impairment (MCI) to Alzheimer's disease (AD) is important for the early intervention and management of AD. The aim of our study was to develop a longitudinal structural magnetic res...
BACKGROUND: Subclinical diastolic dysfunction is a precursor for developing heart failure with preserved ejection fraction (HFpEF); yet not all patients progress to HFpEF. Our objective was to evaluate clinical and echocardiographic variables to iden...
Early identification of individuals at risk of developing Alzheimer's disease (AD) dementia is important for developing disease-modifying therapies. In this study, given multimodal AD markers and clinical diagnosis of an individual from one or more t...
BACKGROUND: Chronic kidney disease (CKD) stage 3 was divided into two subgroups by eGFR (45 mL/ min 1.73 m). There is difference in prevalence of CKD, racial differences, economic development, genetic, and environmental backgrounds between China and ...
BACKGROUND: Asthma exacerbation is an acute or subacute episode of progressive worsening of asthma symptoms and can have a significant impact on patients' quality of life. However, efficient methods that can help identify personalized risk factors an...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Jul 30, 2020
INTRODUCTION: Identifying cognitively normal individuals at high risk for progression to symptomatic Alzheimer's disease (AD) is critical for early intervention.
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