AIMC Topic: Drug Compounding

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Neurotoxicity of intraneural injection of bupivacaine liposome injectable suspension versus bupivacaine hydrochloride in a porcine model.

Veterinary anaesthesia and analgesia Oct 11, 2018
OBJECTIVE: To test whether neurotoxic effects of a bupivacaine liposome injectable suspension differ from those of a standard formulation of bupivacaine hydrochloride (HCl) after intraneural injection into the sciatic nerves in pigs.
Liposomes Drug Compounding Random Allocation Models, Animal Anesthetics, Local Bupivacaine Prospective Studies Sciatic Nerve Female Injections Animals Male Swine
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Comparison of multi-linear regression, particle swarm optimization artificial neural networks and genetic programming in the development of mini-tablets.

International journal of pharmaceutics Sep 15, 2018
In the present study, the preparation of pharmaceutical mini-tablets was attempted in the framework of Quality by Design (QbD) context, by comparing traditionally used multi-linear regression (MLR), with artificially-intelligence based regression tec...
Neural Networks, Computer Drug Design Drug Compounding Tablets Linear Models Starch Lactose Calcium Phosphates Excipients Powders
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Optimization of the Cohesion Index in the SeDeM Diagram Expert System and application of SeDeM Diagram: An improved methodology to determine the Cohesion Index.

PloS one Sep 13, 2018
In this study, we suggest optimizing the methodology to determine the Cohesion Index (Icd) in order to avoid mistaken characterizations due to powder bulk density. For this purpose, five different excipients, with different bulk densities and of diff...
Tablets Powders Expert Systems Models, Theoretical Drug Compounding Excipients Hardness
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A robotic system to prepare IV solutions.

International journal of medical informatics Sep 11, 2018
Drugs need to be used regularly and correctly in order to be effective. When medicines are used correctly, negativities that threaten human health and life can be avoided, but they can cause unwanted situations that can occur until the end of life wh...
Drug Compounding Medication Errors Humans Antineoplastic Agents Robotics Quality Control
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Physicochemical stability of etoposide diluted at range concentrations between 0.38 and 1.75 mg/mL in polyolefin bags.

European journal of hospital pharmacy : science and practice Jul 7, 2018
INTRODUCTION: According to the manufacturers, the diluted solution of etoposide should not exceed 0.4 mg/mL because precipitation may occur. For high doses or for patients requiring fluid restrictions, etoposide phosphate may be an option but shortag...
Drug Packaging Drug Storage Drug Compounding Humans Etoposide Chemical Phenomena Chromatography, High Pressure Liquid Polyenes Pharmaceutical Solutions Drug Stability
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Artificial neural networks (ANNs) and partial least squares (PLS) regression in the quantitative analysis of cocrystal formulations by Raman and ATR-FTIR spectroscopy.

Journal of pharmaceutical and biomedical analysis Jun 4, 2018
The present work describes the development of an efficient, fast and accurate method for the quantification of polymer-based cocrystal formulations. Specifically, the content of carbamazepine-nicotinamide (CBZ/NIC) and ibuprofen-nicotinamide (IBU/NIC...
Neural Networks, Computer Absorption, Physicochemical Calibration Spectroscopy, Fourier Transform Infrared Crystallization Least-Squares Analysis Chemistry, Pharmaceutical Polyethylene Glycols Carbamazepine Drug Compounding Polyvinyls Machine Learning Ibuprofen Spectrum Analysis, Raman Niacinamide Drug Combinations
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Statistical moments in modelling of swelling, erosion and drug release of hydrophilic matrix-tablets.

International journal of pharmaceutics Feb 1, 2018
Statistical moments were evaluated as suitable parameters for describing swelling and erosion processes (along with drug release) in hydrophilic controlled release matrix tablets. The effect of four independent formulation variables, corresponding to...
Polymers Kinetics Tablets Solubility Neural Networks, Computer Water Models, Statistical Drug Carriers Technology, Pharmaceutical Delayed-Action Preparations Nimodipine Drug Liberation Hydrophobic and Hydrophilic Interactions Drug Compounding Linear Models
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A novel method for the production of core-shell microparticles by inverse gelation optimized with artificial intelligent tools.

International journal of pharmaceutics Jan 16, 2018
Numerous studies have been focused on hydrophobic compounds encapsulation as oils. In fact, oils can provide numerous health benefits as synergic ingredient combined with other hydrophobic active ingredients. However, stable microparticles for pharma...
Technology, Pharmaceutical Chemistry, Pharmaceutical Alginates Microspheres Glucuronic Acid Hexuronic Acids Calcium Chloride Sunflower Oil Hydrophobic and Hydrophilic Interactions Drug Compounding Gels Neural Networks, Computer Capsules Artificial Intelligence Fuzzy Logic Equipment Design Emulsions
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Transparent predictive modelling of the twin screw granulation process using a compensated interval type-2 fuzzy system.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V Dec 27, 2017
In this research, a new systematic modelling framework which uses machine learning for describing the granulation process is presented. First, an interval type-2 fuzzy model is elicited in order to predict the properties of the granules produced by t...
Models, Statistical Technology, Pharmaceutical Machine Learning Particle Size Algorithms Dosage Forms Models, Chemical Cellulose Stochastic Processes Drug Compounding Fuzzy Logic
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Stability of infliximab solutions in different temperature and dilution conditions.

Journal of pharmaceutical and biomedical analysis Dec 18, 2017
Infliximab is a monoclonal antibody widely used for the treatment of inflammatory diseases. Over the past few years, many studies have assessed that monoclonal antibodies are prone to aggregation under stress conditions. The aim of this study was to ...
Infliximab Biosimilar Pharmaceuticals Protein Stability Drug Stability Drug Compounding Osmolar Concentration Pharmaceutical Solutions Technology, Pharmaceutical Temperature Time Factors Nanoparticles Spectroscopy, Fourier Transform Infrared Chromatography, Ion Exchange Antirheumatic Agents Nephelometry and Turbidimetry Protein Aggregates Peptide Mapping Spectrophotometry, Ultraviolet Chromatography, Gel
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