Motivated by an ongoing study to develop a screening test able to identify patients with undiagnosed Sjögren's Syndrome in a symptomatic population, we propose methodology to combine multiple biomarkers and evaluate their performance in a two-stage g...
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Feb 4, 2016
Chronic nonhealing wounds have a prevalence of 2% in the United States, and cost an estimated $50 billion annually. Accurate stratification of wounds for risk of slow healing may help guide treatment and referral decisions. We have applied modern mac...
OBJECTIVE: The Internet has become a platform to express individual moods/feelings of daily life, where authors share their thoughts in web blogs, micro-blogs, forums, bulletin board systems or other media. In this work, we investigate text-mining te...
BACKGROUND: The development of MRI based methods could prove extremely valuable for identification of reliable biomarkers to aid diagnosis of neurodegenerative diseases (NDs). A great deal of current research has been aimed at identification biomarke...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common type of dementia among older people. The number of patients with AD will grow rapidly each year and AD is the fifth leading cause of death for those aged 65 and ...
Large-scale aggregate analyses of anonymized data can yield valuable results and insights that address public health challenges and provide new avenues for scientific discovery. These methods can extend our knowledge and provide new tools for enhanci...
IEEE journal of biomedical and health informatics
May 4, 2015
Accurate classification of Alzheimer's disease (AD) and its prodromal stage, mild cognitive impairment (MCI), plays a critical role in possibly preventing progression of memory impairment and improving quality of life for AD patients. Among many rese...
Recently, there has been an increasing emphasis on applications of pattern recognition and neuroimaging techniques in the effective and accurate diagnosis of psychiatric or neurological disorders. In the present study, we investigated the whole-brain...
BACKGROUND: Predicting Posttraumatic Stress Disorder (PTSD) is a pre-requisite for targeted prevention. Current research has identified group-level risk-indicators, many of which (e.g., head trauma, receiving opiates) concern but a subset of survivor...
BACKGROUND: Cardiac valve calcification (CVC) is common in dialysis patients and associated with increased cardiovascular risk. However, early screening has been limited by cost concerns. This study aimed to develop and validate a machine learning mo...
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