AIMC Topic: Environmental Exposure

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Association between exposure to air pollution and kidney function decline.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
BACKGROUND AND HYPOTHESIS: Chronic kidney disease is a major global health concern, with air pollution increasingly recognized as a key contributor to kidney function decline. This study hypothesizes that exposure to air pollution accelerates kidney ...

Association between long-term exposure of polystyrene microplastics and exacerbation of seizure symptoms: Evidence from multiple approaches.

Ecotoxicology and environmental safety
Microplastics are tiny plastic particles originating from both commercial product manufacturing and the degradation of larger plastic materials. These particles pose significant risks to environmental and animal health. A growing body of evidence hig...

Impact of environmental pollution on human health: Investigating the role of Polycyclic Aromatic Hydrocarbons in pediatric osteosarcoma.

Ecotoxicology and environmental safety
BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs), widely emitted through industrial processes and vehicular exhaust, are recognized environmental carcinogens. Although PAH exposure has been linked to various malignancies, the specific molecular me...

Assessing the effect of perfluoroalkyl and polyfluoroalkyl substances on cardiovascular-kidney-metabolic syndrome: Insights from an interpretable machine learning model.

The Science of the total environment
Cardiovascular-kidney-metabolic syndrome (CKM) and its association with exposure to emerging pollutants, particularly perfluoroalkyl and polyfluoroalkyl substances (PFAS), present significant challenges for environmental public health and risk predic...

Interpretable machine learning insights into the association between PFAS exposure and diabetes mellitus.

Ecotoxicology and environmental safety
BACKGROUND: Diabetes Mellitus (DM) is a global health concern with rising prevalence, and its link to PFAS exposure remains unclear. No machine learning (ML) models have yet been developed to predict DM based on PFAS exposure.

Assessing risk of groundwater pollution exposure from sea level rise in California.

The Science of the total environment
Sea level rise (SLR) will cause a groundwater table rise in coastal aquifers, and this can trigger exposure to toxic chemicals via direct contact with contaminated water or through vapor intrusion. This study presents deep learning- and explainable a...

Investigating the potential risk of cadmium exposure on Osteoporosis: An integrated multi-omics approach.

Ecotoxicology and environmental safety
Osteoporosis (OP) is a chronic progressive bone disease, and its occurrence and development under cadmium exposure remain unclear. This study aims to explore the role of cadmium exposure in the pathogenesis of OP through a comprehensive analysis of m...

Association between metal mixture in urine and abnormal blood pressure and mediated effect of oxidative stress based on BKMR and Machine learning method.

Ecotoxicology and environmental safety
BACKGROUND: Exposure to heavy metals represents a significant risk factor for hypertension and blood pressure disorders. Notably, current evidence indicates that the key biological processes of oxidative stress, inflammation, and endothelial dysfunct...

ExposomeX: Development of an Integrative Exposomic Platform to Expedite Discovery of the "Exposure-Biology-Disease" Nexus.

Environmental science & technology
We proposed presenting a novel integrated platform, ExposomeX, that was created to expedite discovery of the "exposure-biology-disease" nexus. This platform has six major functions, i.e., exposome database (E-DB), biological link (E-BIO), statistical...

Non-traditional socio-environmental and geospatial determinants of Alzheimer's disease-related dementia mortality.

The Science of the total environment
IMPORTANCE: Recent data point to the impact of non-traditional environmental and social factors on Alzheimer's Disease-Related Dementias (ADRD) mortality. Our study aimed to determine the extent to which antecedent air pollution, social vulnerability...