AIMC Topic: Extracellular Matrix
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Quantitative image analysis of the extracellular matrix of esophageal squamous cell carcinoma and high grade dysplasia via two-photon microscopy.
Scientific reports
Aug 7, 2025
Squamous cell carcinoma (SCC) and high-grade dysplasia (HGD) are two different pathological entities; however, they sometimes share similarities in histological structure depending on the context. Thus, distinguishing between the two may require care...
Machine learning derived development and validation of extracellular matrix related signature for predicting prognosis in adolescents and young adults glioma.
Scientific reports
Aug 7, 2025
The mortality rates have been increasing for glioma in adolescents and young adults (AYAs, aged 15-39 years). However, current biomarkers for clinical assessment in AYAs glioma are limited, prompting the urgent need for identifying ideal prognostic s...
Machine Learning-Enhanced Single-Particle Tracking for Rapid Screening of Tumor Immunomodulatory Drugs.
ACS nano
Jul 21, 2025
The tumor microenvironment plays a critical role in tumor progression and immune response, with the extracellular matrix (ECM) regulating immune cell infiltration. However, the interplay between ECM dynamics and tumor immunity remains poorly understo...
FIRM image analysis: A machine learning workflow for quantifying extracellular matrix components from electron microscopy images.
PloS one
Feb 6, 2025
The extracellular matrix (ECM) is a complex network of biomolecules that plays an integral role in the structure, processes, and signaling mechanisms of cells and tissues. Identifying and quantifying changes in these matrix components provides insigh...
Machine learning identifies remodeling patterns in human lung extracellular matrix.
Acta biomaterialia
Dec 31, 2024
Organ function depends on the three-dimensional integrity of the extracellular matrix (ECM). The structure resulting from the location and association of ECM components is a central regulator of cell behavior, but a dearth of matrix-specific analysis...
Exploratory study of extracellular matrix biomarkers for non-invasive liver fibrosis staging: A machine learning approach with XGBoost and explainable AI.
Clinical biochemistry
Dec 13, 2024
BACKGROUND: Novel circulating markers for the non-invasive staging of chronic liver disease (CLD) are in high demand. Although underutilized, extracellular matrix (ECM) components offer significant diagnostic potential. This study evaluates ECM-relat...
Combined High-Throughput Proteomics and Random Forest Machine-Learning Approach Differentiates and Classifies Metabolic, Immune, Signaling and ECM Intra-Tumor Heterogeneity of Colorectal Cancer.
Cells
Aug 6, 2024
Colorectal cancer (CRC) is a frequent, worldwide tumor described for its huge complexity, including inter-/intra-heterogeneity and tumor microenvironment (TME) variability. Intra-tumor heterogeneity and its connections with metabolic reprogramming an...
Perineuronal Net Microscopy: From Brain Pathology to Artificial Intelligence.
International journal of molecular sciences
Apr 11, 2024
Perineuronal nets (PNN) are a special highly structured type of extracellular matrix encapsulating synapses on large populations of CNS neurons. PNN undergo structural changes in schizophrenia, epilepsy, Alzheimer's disease, stroke, post-traumatic co...
Multimodal characterization of the collagen hydrogel structure and properties in response to physiologically relevant pH fluctuations.
Acta biomaterialia
Feb 28, 2024
pH fluctuations within the extracellular matrix (ECM) and its principal constituent collagen, particularly in solid tumors and chronic wounds, may influence its structure and function. Whereas previous research examined the impact of pH on collagen f...
Magnetic soft robotics to manipulate the extracellular matrix in vitro.
Cell
Oct 31, 2023
The importance of dynamic mechanical control over the cellular microenvironment has long been appreciated. In a recent issue of Device, Raman and colleagues design a clever yet generalizable tool to achieve this, illustrating magnetic stimulation of ...
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