AIMC Topic: Fatty Acids

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Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features.

The journal of physical chemistry letters Apr 17, 2018
Predicting the activity of chemicals for a given odorant receptor is a longstanding challenge. Here the activity of 258 chemicals on the human G-protein-coupled odorant receptor (OR)51E1, also known as prostate-specific G-protein-coupled receptor 2 (...
Humans Machine Learning Animals Models, Molecular Drug Evaluation, Preclinical Fatty Acids Ligands Receptors, Odorant Protein Binding Mice Receptors, G-Protein-Coupled Neoplasm Proteins
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Individual and Combined Effects of Fumonisin B₁, Deoxynivalenol and Zearalenone on the Hepatic and Renal Membrane Lipid Integrity of Rats.

Toxins Dec 22, 2017
(1) Background and (2) Methods: A 14-day in vivo, multitoxic (pure mycotoxins) rat experiment was conducted with zearalenone (ZEA; 15 μg/animal/day), deoxynivalenol (DON; 30 μg/animal/day) and fumonisin B₁ (FB₁; 150 μg/animal/day), as individual myco...
Animals Membrane Lipids Organ Size Zearalenone Male Fatty Acids Kidney Fumonisins Rats, Wistar Trichothecenes Liver
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Enzymatic preparation of "functional oil" rich in feruloylated structured lipids with solvent-free ultrasound pretreatment.

Food chemistry Dec 19, 2017
In this study, a series of functional oils rich in feruloylated structured lipids (FSLs) was prepared by enzymatic transesterification of ethyl ferulate (EF) with triglycerides under ultrasound pretreatment. A conversion of more than 92.7% and contro...
Triglycerides Fatty Acids Antioxidants Caffeic Acids Solvents Plant Oils Esterification Ultrasonics Lipids Lipase Kinetics
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Activation of PPARα by Oral Clofibrate Increases Renal Fatty Acid Oxidation in Developing Pigs.

International journal of molecular sciences Dec 8, 2017
The objective of this study was to evaluate the effects of peroxisome proliferator-activated receptor α (PPARα) activation by clofibrate on both mitochondrial and peroxisomal fatty acid oxidation in the developing kidney. Ten newborn pigs from 5 litt...
Clofibrate Hydroxymethylglutaryl-CoA Synthase Peroxisomes Animals Mitochondria Swine Fatty Acids Kidney PPAR alpha Oxidation-Reduction 3-Hydroxybutyric Acid Lipid Metabolism
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Quantification of fatty acids in the muscle of Antarctic fish Trematomus bernacchii by gas chromatography-mass spectrometry: Optimization of the analytical methodology.

Chemosphere Dec 31, 2016
This work presents data on the quantification of fatty acids (FAs, in terms of mass unit per tissue weight) in the muscle of Trematomus bernacchii, a key species in Antarctica, often used as bioindicator for contamination studies. Modifications in fa...
Gas Chromatography-Mass Spectrometry Animals Antarctic Regions Perciformes Esterification Fatty Acids Muscles
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Fatty acid composition and mechanisms of the protective effects of myrtle berry seed aqueous extract in alcohol-induced peptic ulcer in rat.

Canadian journal of physiology and pharmacology Nov 10, 2016
This study aimed to investigate the antiulcer and antioxidant activities of myrtle berry seed aqueous extract (MBSAE) in a peptic ulcer model induced by ethanol in male Wistar rats. MBSAE is rich in total polyphenols, total flavonoids, and unsaturate...
Rats Seeds Ethanol Polyphenols Flavonoids Iron Calcium Fatty Acids Water Plant Extracts Duodenum Myrtus Rats, Wistar Animals Male Lipid Peroxidation Hydrogen Peroxide Cytoprotection Peptic Ulcer Stomach
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Adaptations to excess choline in insulin resistant and Pcyt2 deficient skeletal muscle.

Biochemistry and cell biology = Biochimie et biologie cellulaire Sep 6, 2016
It was hypothesized that choline supplementation in insulin resistant (IR) CTP:phosphoethanolamine cytidylyltransferase deficient (Pcyt2) mice would ameliorate muscle function by remodeling glucose and fatty acid (FA) metabolism. Pcyt2 mice either re...
Organic Cation Transport Proteins RNA Nucleotidyltransferases Sterol Regulatory Element Binding Protein 1 fas Receptor Microtubule-Associated Proteins Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Stearoyl-CoA Desaturase Lipogenesis Adaptation, Physiological Carnitine O-Palmitoyltransferase Diacylglycerol O-Acyltransferase Insulin Receptor Substrate Proteins Choline Gene Expression Regulation PPAR alpha Triglycerides Mice, Knockout Glucose Insulin Resistance Fatty Acids Signal Transduction Administration, Oral Muscle, Skeletal Animals Mice
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Revealing disease-associated pathways by network integration of untargeted metabolomics.

Nature methods Aug 1, 2016
Uncovering the molecular context of dysregulated metabolites is crucial to understand pathogenic pathways. However, their system-level analysis has been limited owing to challenges in global metabolite identification. Most metabolite features detecte...
Huntington Disease Databases, Protein Metabolic Networks and Pathways Fatty Acids Sphingolipids Humans Algorithms Steroids Metabolomics Neural Networks, Computer Machine Learning
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Formulation of Granules for Site-Specific Delivery of an Antimicrobial Essential Oil to the Animal Intestinal Tract.

Journal of pharmaceutical sciences Dec 23, 2015
Owing to proliferation of antibiotic-resistant bacteria, the use of antibiotics for livestock growth promotion is banned in many countries and alternatives to in-feed antibiotics are needed. Cinnamon essential oil exhibits strong in vitro antibacteri...
Anti-Infective Agents Drug Delivery Systems Animals Oils, Volatile Body Fluids Fatty Acids Powders Technology, Pharmaceutical Chemistry, Pharmaceutical Intestines Escherichia coli Intestinal Mucosa Polymers Acrolein
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Comparison of response surface methodology and artificial neural network approach towards efficient ultrasound-assisted biodiesel production from muskmelon oil.

Ultrasonics sonochemistry Oct 23, 2014
The present study is to evaluate and compare the prediction and simulating efficiencies of response surface methodology (RSM) and artificial neural network (ANN) based models on fatty acid methyl esters (FAME) yield achieved from muskmelon oil (MMO) ...
Esterification Cucumis Sulfuric Acids Fatty Acids Neural Networks, Computer Esters Plant Oils Ultrasonics Models, Chemical Biofuels
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