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Predicting infections with multidrug-resistant organisms (MDROs) in neurocritical care patients with hospital-acquired pneumonia (HAP): development of a novel multivariate prediction model.
Microbiology spectrum
May 15, 2025
Hospital-acquired pneumonia (HAP) is prevalent in the neuro-intensive care unit (NICU), significantly increasing susceptibility to infections with multidrug-resistant organisms (MDROs), which result in high mortality rates and substantial healthcare ...
Potential Modulatory Roles of Gut Microbiota and Metabolites in the Associations of Macronutrient-to-Physical Activity Ratios With Dyslipidemia.
Journal of the American Heart Association
May 15, 2025
BACKGROUND: Lifestyle factors toward diet and physical activity (PA) may directly influence the pathophysiology of dyslipidemia. However, the associations of the specific macronutrient-to-PA ratio with dyslipidemia, and the underlying mechanisms rega...
Proteomic-based biomarker discovery reveals panels of diagnostic biomarkers for early identification of heart failure subtypes.
Journal of translational medicine
May 15, 2025
BACKGROUND: Limited access to echocardiography can delay the diagnosis of suspected heart failure (HF), which in turn postpones the initiation of optimal guideline-directed medical therapy. Although natriuretic peptides like B-type natriuretic peptid...
Tumor budding and poorly differentiated clusters as a biological continuum in colorectal cancer invasion and prognosis.
Scientific reports
May 15, 2025
Tumor budding (TB) and poorly differentiated clusters (PDCs) are features of infiltrative growth patterns and powerful independent prognostic factors in colorectal cancer (CRC), yet the underlying biological mechanisms behind their role in CRC invasi...
Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets.
Nature communications
May 15, 2025
Coronary artery disease (CAD) is a leading cause of death globally. Antiplatelet therapy remains crucial in preventing and treating CAD-associated thrombotic complications, but it concurrently amplifies the risk of bleeding. Unfortunately, traditiona...
Predicting Immunotherapy Response in Unresectable Hepatocellular Carcinoma: A Comparative Study of Large Language Models and Human Experts.
Journal of medical systems
May 15, 2025
Hepatocellular carcinoma (HCC) is an aggressive cancer with limited biomarkers for predicting immunotherapy response. Recent advancements in large language models (LLMs) like GPT-4, GPT-4o, and Gemini offer the potential for enhancing clinical decisi...
Automated high precision PCOS detection through a segment anything model on super resolution ultrasound ovary images.
Scientific reports
May 15, 2025
PCOS (Poly-Cystic Ovary Syndrome) is a multifaceted disorder that often affects the ovarian morphology of women of their reproductive age, resulting in the development of numerous cysts on the ovaries. Ultrasound imaging typically diagnoses PCOS, whi...
DEVELOPMENT AND VALIDATION OF A PREDICTION MODEL FOR SEPTIC SHOCK-ASSOCIATED ACUTE KIDNEY INJURY: A MULTICENTER STUDY USING NOMOGRAM MODELING.
Shock (Augusta, Ga.)
May 13, 2025
Background: Septic shock-associated acute kidney injury (SS-AKI) is a severe complication with high mortality. This study aimed to investigate the risk factors associated with AKI in patients with septic shock and establish a nomogram to predict its ...
Circulating fibroblast growth factor 21 is associated with blood pressure in the Chinese population: a community-based study.
Annals of medicine
May 12, 2025
BACKGROUND: Our research team previously found that fibroblast growth factor (FGF) 21, a circulating hormone, was significantly associated with atherosclerosis in human and animal models. The relationship between FGF21 and blood pressure (BP) is rare...
Identification of nanoparticle infiltration in human breast milk: Chemical profiles and trajectory pathways.
Proceedings of the National Academy of Sciences of the United States of America
May 12, 2025
Breast milk is crucial for infant health, offering essential nutrients and immune protection. However, despite increasing exposure risks from nanoparticles (NPs), their potential infiltration into human breast milk remains poorly understood. This stu...
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