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Development and Validation of a Cell-Free DNA Fragmentomics-Based Model for Early Detection of Pancreatic Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
May 1, 2025
PURPOSE: Pancreatic ductal adenocarcinoma (PDAC), known for its high fatality rate, is often diagnosed in its advanced stages where surgical options are not viable. This highlights the critical need for innovative and effective early detection techni...
Reirradiation for recurrent glioblastoma: the significance of the residual tumor volume.
Journal of neuro-oncology
May 1, 2025
PURPOSE: Recurrent glioblastoma has a poor prognosis, and its optimal management remains unclear. Reirradiation (re-RT) is a promising treatment option, but long-term outcomes and optimal patient selection criteria are not well established.
Forecasting optimal treatments in relapsed/refractory mature T- and NK-cell lymphomas: A global PETAL Consortium study.
British journal of haematology
May 1, 2025
There is no standard of care in relapsed/refractory T-cell/natural killer-cell lymphomas. Patients often cycle through cytotoxic chemotherapy (CC), epigenetic modifiers (EM) or small molecule inhibitors (SMI) empirically. Ideal therapy at each line r...
Machine Learning for Predicting Critical Events Among Hospitalized Children.
JAMA network open
May 1, 2025
IMPORTANCE: Unrecognized deterioration among hospitalized children is associated with a high risk of mortality and morbidity. The current approach to pediatric risk stratification is fragmented, as each hospital unit (emergency, ward, or intensive ca...
Dedicated AI Expert System vs Generative AI With Large Language Model for Clinical Diagnoses.
JAMA network open
May 1, 2025
IMPORTANCE: Large language models (LLMs) have not yet been compared with traditional diagnostic decision support systems (DDSSs) on unpublished clinical cases.
The Impact of Telepresence Robots on Family Caregivers and Residents in Long-Term Care.
International journal of environmental research and public health
May 1, 2025
Telepresence robots can enhance social connection and support person-centered care in long-term care (LTC) homes. This study evaluates their impact in facilitating virtual visits between family caregivers and older residents in Canadian LTC homes. Te...
Machine Learning Multimodal Model for Delirium Risk Stratification.
JAMA network open
May 1, 2025
IMPORTANCE: Automating the identification of risk for developing hospital delirium with models that use machine learning (ML) could facilitate more rapid prevention, identification, and treatment of delirium. However, there are very few reports on th...
A deep learning algorithm for automated adrenal gland segmentation on non-contrast CT images.
BMC medical imaging
May 1, 2025
BACKGROUND: The adrenal glands are small retroperitoneal organs, few reference standards exist for adrenal CT measurements in clinical practice. This study aims to develop a deep learning (DL) model for automated adrenal gland segmentation on non-con...
Global burden of non-melanoma skin cancers among older adults: a comprehensive analysis using machine learning approaches.
Scientific reports
May 1, 2025
Non-melanoma skin cancers (NMSCs), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), have shown significant global increases in burden, particularly among older adults, with wide regional, gender, and socio-demographic dispariti...
Identification of relevant features using SEQENS to improve supervised machine learning models predicting AML treatment outcome.
BMC medical informatics and decision making
May 1, 2025
BACKGROUND AND OBJECTIVE: This study has two main objectives. First, to evaluate a feature selection methodology based on SEQENS, an algorithm for identifying relevant variables. Second, to validate machine learning models that predict the risk of co...
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