AIMC Topic: Fluorescent Antibody Technique
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Manipulation of Single Neural Stem Cells and Neurons in Brain Slices using Robotic Microinjection.
Journal of visualized experiments : JoVE
Jan 21, 2021
A central question in developmental neurobiology is how neural stem and progenitor cells form the brain. To answer this question, one needs to label, manipulate, and follow single cells in the brain tissue with high resolution over time. This task is...
Comparing convolutional neural networks and preprocessing techniques for HEp-2 cell classification in immunofluorescence images.
Computers in biology and medicine
Nov 20, 2019
Autoimmune diseases are the third highest cause of mortality in the world, and the identification of an anti-nuclear antibody via an immunofluorescence test for HEp-2 cells is a standard procedure to support diagnosis. In this work, we assess the per...
Deep-UV excitation fluorescence microscopy for detection of lymph node metastasis using deep neural network.
Scientific reports
Nov 15, 2019
Deep-UV (DUV) excitation fluorescence microscopy has potential to provide rapid diagnosis with simple technique comparing to conventional histopathology based on hematoxylin and eosin (H&E) staining. We established a fluorescent staining protocol for...
Utilizing supervised machine learning to identify microglia and astrocytes in situ: implications for large-scale image analysis and quantification.
Journal of neuroscience methods
Sep 5, 2019
BACKGROUND: The evaluation of histological tissue samples plays a crucial role in deciphering preclinical disease and injury mechanisms. High-resolution images can be obtained quickly however data acquisition are often bottlenecked by manual analysis...
Analogous detection of circulating tumor cells using the AccuCyte -CyteFinder system and ISET system in patients with locally advanced and metastatic prostate cancer.
The Prostate
Dec 29, 2017
INTRODUCTION: Circulating tumor cells (CTCs) can provide important information on patient's prognosis and treatment efficacy. Currently, a plethora of methods is available for the detection of these rare cells. We compared the outcomes of two of thos...
Development of a Competitive Time-Resolved Fluoroimmunoassay for Paclitaxel.
Phytochemical analysis : PCA
Dec 20, 2017
INTRODUCTION: Paclitaxel (Tax) is a diterpene alkaloid isolated from Taxus species and has proved clinically effective in treating a number of malignancies. Current quantitative analytical methods for Tax such as high-performance liquid chromatograph...
Automating cell detection and classification in human brain fluorescent microscopy images using dictionary learning and sparse coding.
Journal of neuroscience methods
Mar 4, 2017
BACKGROUND: Immunofluorescence (IF) plays a major role in quantifying protein expression in situ and understanding cell function. It is widely applied in assessing disease mechanisms and in drug discovery research. Automation of IF analysis can trans...
Incorporating organelle correlations into semi-supervised learning for protein subcellular localization prediction.
Bioinformatics (Oxford, England)
Apr 23, 2016
MOTIVATION: Bioimages of subcellular protein distribution as a new data source have attracted much attention in the field of automated prediction of proteins subcellular localization. Performance of existing systems is significantly limited by the sm...
Nuquantus: Machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images.
Scientific reports
Mar 23, 2016
Determination of fundamental mechanisms of disease often hinges on histopathology visualization and quantitative image analysis. Currently, the analysis of multi-channel fluorescence tissue images is primarily achieved by manual measurements of tissu...
Automatic recognition of protein subcellular location patterns in single cells from immunofluorescence images based on deep learning.
Briefings in bioinformatics
Jan 19, 2023
With the improvement of single-cell measurement techniques, there is a growing awareness that individual differences exist among cells, and protein expression distribution can vary across cells in the same tissue or cell line. Pinpointing the protein...
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