Triple-negative breast cancer (TNBC) is notorious for its rapid progression, tendency to metastasize, high recurrence rates, dismal outcomes, and limited treatment options, underscoring the urgent need to uncover new biomarkers and molecular pathways...
Cell-to-cell communication through ligand-receptor (LR) interactions can fundamentally shape the tumor microenvironment and immune responses, but the full spectrum of these interactions in anti-PD-1 therapy remains unexplored. We developed a predicti...
Non-small cell lung cancer (NSCLC) remains a major health challenge worldwide, mainly due to the lack of effective early diagnostic biomarkers. Exosome-related genes have recently emerged as potential diagnostic markers due to their roles in tumor pr...
Ischemic stroke (IS) is an acute neurological disorder causing brain dysfunction, with high mortality and disability. PANoptosis is a synchronized sort of regulated cell demise that combines the characteristics of pyroptosis, apoptosis, and necroptos...
Hepatocellular carcinoma (HCC) is a biologically and clinically heterogeneous malignancy, whose initiation and progression are increasingly recognized to be driven by the aberrant regulation of programmed cell death (PCD) pathways. To elucidate this ...
This study investigated dynamic brain network changes and their genetic correlations in children with idiopathic generalized epilepsy (IGE). We included 26 children with IGE and 35 healthy controls, all participants underwent resting-state functional...
Biochemical and biophysical research communications
Oct 21, 2025
BACKGROUND: Bicuspid aortic valve (BAV), the most common congenital heart defect, is strongly predisposed to early calcification, yet the molecular drivers remain poorly defined. This study aims to identify the functional role of transient receptor p...
Endometriosis (EMs) and recurrent miscarriage (RM) represent major reproductive health challenges. This study investigates the involvement of endothelial-mesenchymal transition (EndMT) in these conditions through integrative bioinformatics analysis, ...
The primary aim of our study was to address the problem of transcriptomic data complexity by introducing a novel transcriptomic response index (TRI), compressing the entire transcriptomic space into a single variable, and linking it with the inhaled ...
BACKGROUND: Obesity has emerged as a major global public health challenge and poses a significant threat to human health. Despite extensive research, the mechanisms underlying its pathological progression remain elusive.
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