AIMC Topic: Gene Expression Regulation, Neoplastic
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Preoperative MRI-based radiomics analysis of intra- and peritumoral regions for predicting CD3 expression in early cervical cancer.
Scientific reports
Jul 23, 2025
The study investigates the correlation between CD3 T-cell expression levels and cervical cancer (CC) while developing a magnetic resonance (MR) imaging-based radiomics model for preoperative prediction of CD3 T-cell expression levels. Prognostic corr...
An autoencoder learning method for predicting breast cancer subtypes.
PloS one
Jul 23, 2025
Heterogeneity of breast cancer poses several challenges for detection and treatment. With next-generation sequencing, we can now map the transcriptional profile of each patient's breast tissue, which has the potential for identifying and characterizi...
Establishment of two pathomic-based machine learning models to predict CLCA1 expression in colon adenocarcinoma.
PloS one
Jul 21, 2025
Chloride channel accessory 1 (CLCA1) is considered a potential prognostic biomarker for colon adenocarcinoma (COAD). The objective of this research was to develop two pathomics models to predict CLCA1 expression from hematoxylin-eosin (H&E) stained p...
Using machine learning to discover DNA metabolism biomarkers that direct prostate cancer treatment.
Scientific reports
Jul 18, 2025
DNA metabolism genes play pivotal roles in the regulation of cellular processes that contribute to cancer progression, immune modulation, and therapeutic response in prostate cancer (PC). Understanding the mechanisms by which these genes influence th...
Integrating bulk and single cell sequencing data to identify prognostic biomarkers and drug candidates in HBV associated hepatocellular carcinoma.
Scientific reports
Jul 18, 2025
Hepatitis B virus (HBV) infection is a major driver of hepatocellular carcinoma (HCC), yet the mechanisms by which HBV triggers HCC and how it interacts with the immune system remain largely undefined. In this study, 53 immune-related key genes invol...
Multi-transcriptomics predicts clinical outcome in systemically untreated breast cancer patients with extensive follow-up.
Breast cancer research : BCR
Jul 15, 2025
BACKGROUND: Prognostic tools for determining patients with indolent breast cancers (BCs) are far from optimal, leading to extensive overtreatment. Several studies have demonstrated mRNAs, lncRNAs and miRNAs to have prognostic potential in BC. Because...
Developing angiogenesis-related prognostic biomarkers and therapeutic strategies in bladder cancer using deep learning and machine learning.
Scientific reports
Jul 15, 2025
Bladder cancer (BLCA) is a prevalent urological malignancy that exhibits a high degree of tumor heterogeneity and morbidity. Tumor angiogenesis, a vital hallmark of cancer, greatly influences the tumor microenvironment (TME). The emergence of anti-an...
A comprehensive analysis of transcription factors identified TCF3 as a prognostic target for glioma.
Scientific reports
Jul 13, 2025
Transcription factors (TFs) are pivotal in tumor initiation and progression, regulating downstream gene expression and modulating cellular processes. In this study, we conducted a comprehensive analysis of TF gene sets to define the molecular subtype...
Mutation
Transcription Factors
Glioma
Basic Helix-Loop-Helix Transcription Factors
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Gene Expression Profiling
Protein Interaction Maps
Gene Regulatory Networks
Gene Expression Regulation, Neoplastic
Humans
Prognosis
Biomarkers, Tumor
Brain Neoplasms
SPP1 promotes malignant characteristics and drug resistance in hepatocellular carcinoma by activating fatty acid metabolic pathway.
Functional & integrative genomics
Jul 11, 2025
Hepatocellular carcinoma (HCC) progression and prognosis are influenced by various molecular markers. This study aimed to identify the hub gene associated with HCC clinical characteristics and its role in HCC progression. Differentially expressed gen...
Comprehensive multi-omics and machine learning framework for glioma subtyping and precision therapeutics.
Scientific reports
Jul 10, 2025
Glioma is a highly heterogeneous and aggressive brain tumour that demands an integrated understanding of its molecular and immunological landscape. We collected multi-omics data from 575 TCGA diffuse-glioma patients (156 IDH-wild-type WHO-grade 4 gli...
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