AIMC Topic: Gene Expression Regulation, Neoplastic
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Machine learning and multi-omics analysis reveal key regulators of proneural-mesenchymal transition in glioblastoma.
Scientific reports
Jun 5, 2025
Glioblastoma (GBM) is classified into subtypes according to the molecular expression profile; the proneural subtype has a relatively good prognosis, and the mesenchymal type is the most aggressive form with the worst prognosis. GBM undergoes proneura...
Machine learning-based integration develops relapse related signature for predicting prognosis and indicating immune microenvironment infiltration in breast cancer.
Scientific reports
Jun 5, 2025
Breast cancer is the most common type of cancer in women, and while current treatments can cure the majority of early-stage primary BC cases, recurrence remains a significant challenge. Traditional methods of assessing patient prognosis, such as AJCC...
Targeting INF2 with DiosMetin 7-O-β-D-Glucuronide: a new stratagem for colorectal cancer therapy.
BMC cancer
Jun 1, 2025
BACKGROUND AND PURPOSE: Colorectal cancer (CRC) is the third most prevalent malignancy in the gastrointestinal tract and the second leading cause of cancer-related deaths. Despite the identification of numerous biomarkers, their non-specific distribu...
Multi-omics identifies OSM-OSMR as a key receptor-ligand in the tumor environment of endometrial adenocarcinoma.
International immunopharmacology
May 31, 2025
Endometrial adenocarcinoma carries a bleak prognosis, and the molecular markers that evaluate the progression of endometrial adenocarcinoma to advanced stages remain uncertain. Cell-cell communication plays a crucial role in the tumor microenvironmen...
Humans
Oncostatin M
Oncostatin M Receptor beta Subunit
Multiomics
Gene Expression Regulation, Neoplastic
Cell Proliferation
Signal Transduction
Adenocarcinoma
Mice, Nude
Gene Expression Profiling
Ligands
Transcriptome
Endometrial Neoplasms
Prognosis
Cell Line, Tumor
Female
Mice
Tumor Microenvironment
Animals
Discovery of novel diagnostic biomarkers of hepatocellular carcinoma associated with immune infiltration.
Annals of medicine
May 29, 2025
OBJECTIVE: Diagnosis of hepatocellular carcinoma (HCC) remains challenging for clinicians. Machine learning approaches and big data analyses are viable strategies for identifying HCC diagnostic markers.
Disulfide bond-related gene signature development for bladder cancer prognosis prediction and immune microenvironment characterization.
Scientific reports
May 29, 2025
Bladder cancer is the fourth most common malignant tumor in men, with limited therapeutic biomarkers and heterogeneous responses to immunotherapy. Disulfide bond-driven cell death has emerged as a critical regulator of tumor progression and immune mi...
Immunological biomarkers and gene signatures predictive of radiotherapy resistance in non-small cell lung cancer.
Frontiers in immunology
May 29, 2025
INTRODUCTION: A significant challenge in treating non-small cell lung cancer (NSCLC) is its inherent resistance to radiation therapy, leading to poor patient prognosis. This study aimed to identify key genes influencing radiotherapy resistance in NSC...
The Role of PANoptosis-Related Genes in Predicting Breast Cancer Survival and Immune Prospect.
BioMed research international
May 28, 2025
The function of PANoptosis in breast cancer (BC) remains indistinct. We constructed a nomogram model to predict the prognosis of BC to identify high-risk patients and help them receive more accurate treatment. We used Cox regression and least absol...
Machine learning-based diagnostic and prognostic models for breast cancer: a new frontier on the clinical application of natural killer cell-related gene signatures in precision medicine.
Frontiers in immunology
May 27, 2025
BACKGROUND: Breast cancer (BC) remains a leading cause of cancer-related mortality among women worldwide. Natural killer (NK) cells play a crucial role in the innate immune system and exhibit significant anti-tumor activity. However, the role of NK c...
Identification and validation of prognostic genes associated with T-cell exhaustion and macrophage polarization in breast cancer.
Frontiers in endocrinology
May 27, 2025
BACKGROUND: The most frequent malignant tumor in women is breast cancer (BRCA). It has been discovered that T-cell exhaustion and macrophages play significant roles in BRCA. It was necessary to explore prognostic genes associated with T-cell exhausti...
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