AIMC Topic: Gene Expression Regulation, Neoplastic

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Identification of recurrent risk-related genes and establishment of support vector machine prediction model for gastric cancer.

Neoplasma Mar 14, 2018
This study sought to investigate genes related to recurrent risk and establish a support vector machine (SVM) classifier for prediction of recurrent risk in gastric cancer (GC).Based on the gene expression profiling dataset GSE26253, feature genes th...
Stomach Neoplasms Gene Expression Profiling Gene Expression Regulation, Neoplastic Support Vector Machine Neoplasm Recurrence, Local Humans
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BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery.

Nucleic acids research Jan 4, 2018
Single-nucleotide variation and gene expression of disease samples represent important resources for biomarker discovery. Many databases have been built to host and make available such data to the community, but these databases are frequently limited...
Biomarkers, Tumor Neoplasms User-Computer Interface Gene Expression Regulation, Neoplastic Mutation Knowledge Bases Databases, Genetic MicroRNAs Humans
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Electronic Health Record Phenotypes for Precision Medicine: Perspectives and Caveats From Treatment of Breast Cancer at a Single Institution.

Clinical and translational science Jan 1, 2018
Precision medicine is at the forefront of biomedical research. Cancer registries provide rich perspectives and electronic health records (EHRs) are commonly utilized to gather additional clinical data elements needed for translational research. Howev...
Breast Neoplasms Gene Expression Regulation, Neoplastic Natural Language Processing Receptor, ErbB-2 Phenotype Precision Medicine Electronic Health Records Female Receptors, Estrogen Antineoplastic Agents, Hormonal Receptors, Progesterone Humans
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Image-based surrogate biomarkers for molecular subtypes of colorectal cancer.

Bioinformatics (Oxford, England) Jul 1, 2017
MOTIVATION: Whole genome expression profiling of large cohorts of different types of cancer led to the identification of distinct molecular subcategories (subtypes) that may partially explain the observed inter-tumoral heterogeneity. This is also the...
Humans Image Processing, Computer-Assisted Neural Networks, Computer Gene Expression Regulation, Neoplastic Prognosis Colorectal Neoplasms Support Vector Machine Biomarkers, Tumor
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Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer.

Oncotarget Apr 18, 2017
We demonstrate that model-based unsupervised learning can uniquely discriminate single-cell subpopulations by their gene expression distributions, which in turn allow us to identify specific genes for focused functional studies. This method was appli...
Gene Expression Profiling Cell Line, Tumor Computational Biology Gene Expression Regulation, Neoplastic Humans Female Breast Neoplasms AMP-Activated Protein Kinases Metformin Gene Knockdown Techniques cdc42 GTP-Binding Protein Signal Transduction Cell Movement Cluster Analysis Unsupervised Machine Learning
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Support Vector Machine Based on microRNA Expression Profiles to Predict Histological Origin of Ampullary Carcinoma: Case Report of a Patient Affected From Adenocarcinoma of the Papilla of Vater With Lynch Syndrome.

Pancreas Apr 1, 2016
Adenocarcinomas of Vater's papilla (PVAC) may originate from either the pancreatic duct or the intestinal epithelium. Conflicting data have been reported about the frequency of the 2 anatomical entities and their influence on patients' prognosis. To ...
Pancreatic Ducts Adenocarcinoma Support Vector Machine MicroRNAs Pancreatic Neoplasms Pedigree Colorectal Neoplasms, Hereditary Nonpolyposis Ampulla of Vater Carcinoma Family Health Gene Expression Profiling Adolescent Child Gene Expression Regulation, Neoplastic Young Adult Humans Adult Prognosis Male Female Middle Aged
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Intraoperative Diagnosis Support Tool for Serous Ovarian Tumors Based on Microarray Data Using Multicategory Machine Learning.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Jan 1, 2016
OBJECTIVES: Serous borderline ovarian tumors (SBOTs) are a subtype of serous ovarian carcinoma with atypical proliferation. Frozen-section diagnosis has been used as an intraoperative diagnosis tool in supporting the fertility-sparing surgery by diag...
Humans Machine Learning Prognosis Biomarkers, Tumor Gene Expression Profiling Monitoring, Intraoperative Female Survival Rate Blotting, Western Support Vector Machine Real-Time Polymerase Chain Reaction Neoplasm Staging Databases, Genetic Neoplasms, Glandular and Epithelial Reverse Transcriptase Polymerase Chain Reaction Ovarian Neoplasms Carcinoma, Ovarian Epithelial Cystadenocarcinoma, Serous RNA, Messenger Predictive Value of Tests Immunoenzyme Techniques Gene Expression Regulation, Neoplastic
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[Study of FN1 and ZNF438 gene expression negatively regulated by androgen receptor in androgen-independent LNCaP cells].

Zhonghua yi xue za zhi Dec 19, 2015
OBJECTIVE: To verify whether FN1 and ZNF438 are the androgen receptor(AR) target genes in LNCaP-AI cells and investigate the effects of AR exerts on FN1 and ZNF438 gene expression.
Gene Expression Regulation, Neoplastic Fibronectins Humans Repressor Proteins Gene Expression Male Down-Regulation Androgens Blotting, Western Receptors, Androgen Cell Line, Tumor Prostatic Neoplasms Dihydrotestosterone Oligonucleotide Array Sequence Analysis RNA, Messenger
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A systematic approach to prioritize drug targets using machine learning, a molecular descriptor-based classification model, and high-throughput screening of plant derived molecules: a case study in oral cancer.

Molecular bioSystems Dec 1, 2015
Systems-biology inspired identification of drug targets and machine learning-based screening of small molecules which modulate their activity have the potential to revolutionize modern drug discovery by complementing conventional methods. To utilize ...
Protein Interaction Mapping Cell Line, Tumor ROC Curve Gene Regulatory Networks Protein Binding Mouth Neoplasms Computational Biology Humans High-Throughput Screening Assays Machine Learning Molecular Conformation Gene Expression Regulation, Neoplastic Drug Discovery Binding Sites Antineoplastic Agents, Phytogenic Receptors, CXCR4 Models, Molecular
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Regulation of demethylation and re-expression of RASSF1A gene in hepatocellular carcinoma cell lines treated with NCTD in vitro.

Journal of cancer research and therapeutics Jan 1, 2015
BACKGROUND: Hepatocellular carcinoma, a lethal malignant neoplasm with poor prognosis, has dismal results of surgical resection and chemoradiotherapy. Norcantharidin (NCTD), the demethylated analog of cantharidin derived from a traditional Chinese me...
DNA Methylation Blotting, Western Tumor Suppressor Proteins Bridged Bicyclo Compounds, Heterocyclic In Vitro Techniques Liver Neoplasms Carcinoma, Hepatocellular Gene Expression Regulation, Neoplastic Humans Tumor Cells, Cultured
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