AIMC Topic: Glucocorticoids

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Effect of congenital adrenal hyperplasia treated by glucocorticoids on plasma metabolome: a machine-learning-based analysis.

Scientific reports Jun 1, 2020
BACKGROUND: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency leads to impaired cortisol biosynthesis. Treatment includes glucocorticoid supplementation. We studied the specific metabolomics signatures in CAH patients using two di...
Adrenal Hyperplasia, Congenital Pyrimidines Indoleamine-Pyrrole 2,3,-Dioxygenase Metabolome Area Under Curve Hydrocortisone Purines Machine Learning Female Humans Young Adult Adult Male Glucocorticoids Case-Control Studies ROC Curve Metabolomics
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Augmented Intelligence Dermatology: Deep Neural Networks Empower Medical Professionals in Diagnosing Skin Cancer and Predicting Treatment Options for 134 Skin Disorders.

The Journal of investigative dermatology Mar 31, 2020
Although deep learning algorithms have demonstrated expert-level performance, previous efforts were mostly binary classifications of limited disorders. We trained an algorithm with 220,680 images of 174 disorders and validated it using Edinburgh (1,3...
Dermoscopy Aged Young Adult Adult Male Humans Anti-Bacterial Agents Female Skin Neoplasms ROC Curve Antiviral Agents Antifungal Agents Skin Feasibility Studies Middle Aged Glucocorticoids Deep Learning Clinical Competence Adolescent Datasets as Topic Photography Internship and Residency Drug Therapy, Computer-Assisted Dermatologists Skin Diseases Dermatology Image Interpretation, Computer-Assisted
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Patient discussions of glucocorticoid-related side effects within an online health community forum.

Annals of the rheumatic diseases Mar 25, 2020
Humans Machine Learning Glucocorticoids Arthritis, Rheumatoid Social Media Data Mining
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Support vector machines for explaining physiological stress response in Wood mice (Apodemus sylvaticus).

Scientific reports Feb 7, 2018
Physiological stress response is a crucial adaptive mechanism for prey species survival. This paper aims to identify the main environmental and/or individual factors better explaining the stress response in Wood mice, Apodemus sylvaticus. We analyzed...
Stress, Physiological Behavior, Animal Murinae Glucocorticoids Feces Mice Support Vector Machine Body Weight Animals
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The Role of Preoperative Steroids for Hearing Preservation Cochlear Implantation: Results of a Randomized Controlled Trial.

Audiology & neuro-otology Jan 13, 2018
OBJECTIVES: To determine whether preoperative steroids can improve hearing outcomes in cochlear implantation (CI).
Cochlear Implantation Deafness Hearing Dexamethasone Prednisolone Preoperative Care Audiometry, Pure-Tone Aged Male Middle Aged Glucocorticoids Treatment Outcome Humans Female
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Efficacy and safety of lebrikizumab in adult patients with mild-to-moderate asthma not receiving inhaled corticosteroids.

Respiratory medicine Dec 13, 2017
BACKGROUND: Asthma is a heterogeneous and complex disease in both its clinical course and response to treatment. IL-13 is central to Type 2 inflammation and contributes to many features of asthma. In a previous Phase 2 study, lebrikizumab, an anti-IL...
Administration, Inhalation Treatment Outcome Anti-Asthmatic Agents Forced Expiratory Volume Male Cyclopropanes Humans Acetates Middle Aged Antibodies, Monoclonal Sulfides Female Glucocorticoids Double-Blind Method Treatment Failure Adult Severity of Illness Index Quinolines Asthma Injections, Subcutaneous
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Increased Cardiovascular Risk in Patients with Adrenal Insufficiency: A Short Review.

BioMed research international Dec 10, 2017
Cardiovascular disease (CVD) is the most common cause of death in the world. Recent studies have shown an association between adrenal insufficiency (AI) and increased cardiovascular risk (CVR). Patients with AI receive glucocorticoid (GC) replacement...
Cardiovascular Diseases Glucocorticoids Hormone Replacement Therapy Adrenal Insufficiency Hydrocortisone Humans Risk Factors Inflammation Mediators Prednisolone Cardiovascular System
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A randomised, phase III trial of once-daily fluticasone furoate/vilanterol 100/25 μg versus once-daily vilanterol 25 μg to evaluate the contribution on lung function of fluticasone furoate in the combination in patients with COPD.

Respiratory medicine Dec 2, 2016
BACKGROUND: The contribution of fluticasone furoate (FF) on lung function in the FF/vilanterol (VI) 100/25 μg combination has been demonstrated numerically, but not statistically.
Aged Adult Pulmonary Disease, Chronic Obstructive Male Middle Aged Glucocorticoids Quality of Life Drug Combinations Double-Blind Method Humans Female Androstadienes Forced Expiratory Volume Adrenergic beta-2 Receptor Agonists Drug Administration Schedule Benzyl Alcohols Kaplan-Meier Estimate Chlorobenzenes Administration, Inhalation
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Pharmacokinetics, Safety, and Tolerability of Once-Daily Intranasal Fluticasone Furoate and Levocabastine Administered Alone or Simultaneously as fluticasone Furoate/Levocabastine Fixed-Dose Combination.

Clinical pharmacology in drug development Dec 4, 2015
PURPOSE: The purpose of this study was to investigate potential systemic pharmacokinetic interactions between intranasal fluticasone furoate (FF) and levocabastine (LEVO) when delivered simultaneously via a metered atomizing spray pump.
Androstadienes Administration, Intranasal Histamine H1 Antagonists, Non-Sedating Female Young Adult Adult Male Middle Aged Glucocorticoids Drug Combinations Biological Availability Cross-Over Studies Humans Piperidines
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A tailored machine learning approach for mortality prediction in severe COVID-19 treated with glucocorticoids.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Sep 1, 2024
BACKGROUNDThe impact of severe COVID-19 pneumonia on healthcare systems highlighted the need for accurate predictions to improve patient outcomes. Despite the established efficacy of glucocorticoids (GCs), variable patient respons...
Humans Machine Learning Male Middle Aged Glucocorticoids Severity of Illness Index COVID-19 Drug Treatment COVID-19 Retrospective Studies Female SARS-CoV-2 Aged
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