AIMC Topic: HEK293 Cells
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Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor α Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells.
Lipids
Feb 1, 2019
Increasing apolipoprotein A-I (apoA-I), the predominant protein of high-density lipoprotein (HDL) particles, has favorable effects on atherogenic risk factors. Here, we investigated the effects of peroxisome proliferator-activated receptor α (PPARα) ...
Hypoxia-responsive micelles self-assembled from amphiphilic block copolymers for the controlled release of anticancer drugs.
Journal of materials chemistry. B
Dec 12, 2018
Amphiphilic block copolymers poly(ethylene glycol)-block-poly(methacrylic acid-co-2-nitroimidazole methacrylate) (PEG-b-P(MAA-co-NIMA)) were synthesized by the combination of atom transfer radical polymerization (ATRP), hydrolysis and EDC reactions. ...
Predictable and precise template-free CRISPR editing of pathogenic variants.
Nature
Nov 7, 2018
Following Cas9 cleavage, DNA repair without a donor template is generally considered stochastic, heterogeneous and impractical beyond gene disruption. Here, we show that template-free Cas9 editing is predictable and capable of precise repair to a pre...
Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production.
PloS one
Aug 2, 2018
The production of envelope glycoproteins (Envs) for use as HIV vaccines is challenging. The yield of Envs expressed in stable Chinese Hamster Ovary (CHO) cell lines is typically 10-100 fold lower than other glycoproteins of pharmaceutical interest. M...
A Supervised Ensemble Approach for Sensitive microRNA Target Prediction.
IEEE/ACM transactions on computational biology and bioinformatics
Jul 20, 2018
MicroRNAs, a class of small non-coding RNAs, regulate important biological functions via post-transcriptional regulation of messenger RNAs (mRNAs). Despite rapid development in miRNA research, precise experimental methods to determine miRNA target in...
A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters.
Nature chemical biology
Feb 26, 2018
We developed a new way to engineer complex proteins toward multidimensional specifications using a simple, yet scalable, directed evolution strategy. By robotically picking mammalian cells that were identified, under a microscope, as expressing prote...
Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase.
Clinical pharmacology and therapeutics
Feb 2, 2018
Deleterious variants in dihydropyrimidine dehydrogenase (DPD, DPYD gene) can be highly predictive of clinical toxicity to the widely prescribed chemotherapeutic 5-fluorouracil (5-FU). However, there are very limited data pertaining to the functional ...
Humans
Machine Learning
Computer Simulation
Cell Survival
Predictive Value of Tests
Structure-Activity Relationship
Models, Molecular
Fluorouracil
Risk Assessment
Pharmacogenetics
Genotype
Dose-Response Relationship, Drug
Pharmacogenomic Variants
Protein Conformation
Antimetabolites, Antineoplastic
Inhibitory Concentration 50
Mutation, Missense
HCT116 Cells
Dihydrouracil Dehydrogenase (NADP)
HEK293 Cells
Pharmacogenomic Testing
Gene Frequency
De Novo Design of Bioactive Small Molecules by Artificial Intelligence.
Molecular informatics
Jan 10, 2018
Generative artificial intelligence offers a fresh view on molecular design. We present the first-time prospective application of a deep learning model for designing new druglike compounds with desired activities. For this purpose, we trained a recurr...
A novel method for the rapid detection of post-translationally modified visinin-like protein 1 in rat models of brain injury.
Brain injury
Dec 28, 2017
BACKGROUND: Although elevated serum levels of visinin-like protein 1 (VILIP-1), a neuron-specific calcium sensor protein, are associated with ischaemic stroke, only a single study has evaluated VILIP-1 as a biomarker of traumatic brain injury (TBI). ...
Graphene oxide-doping improves the biocompatibility and separation performance of polyethersulfone hollow fiber membranes for bioartificial kidney application.
Journal of colloid and interface science
Dec 27, 2017
HYPOTHESIS: Graphene oxide (GO)-doping in polyethersulfone hollow fiber membranes (PES HFMs) improves the biocompatibility and separation performance for bioartificial kidney (BAK) application.
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