AIMC Topic: Humans

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Predictive model of ulcerative colitis syndrome with ensemble learning and interpretability methods.

Scientific reports
In recent years, the prevalence of chronic diseases such as Ulcerative Colitis (UC) has increased, bringing a heavy burden to healthcare systems. Traditional Chinese Medicine (TCM) stands out for its cost-effective and efficient treatment modalities,...

Lessons learned from RadiologyNET foundation models for transfer learning in medical radiology.

Scientific reports
Deep learning models require large amounts of annotated data, which are hard to obtain in the medical field, as the annotation process is laborious and depends on expert knowledge. This data scarcity hinders a model's ability to generalise effectivel...

Anterior cruciate ligament tear detection based on Res2Net modified by improved Lévy flight distribution.

Scientific reports
Anterior Cruciate Ligament (ACL) tears are common in sports and can provide noteworthy health issues. Therefore, accurately diagnosing of tears is important for the early and proper treatment. However, traditional diagnostic methods, such as clinical...

Language models learn to represent antigenic properties of human influenza A(H3) virus.

Scientific reports
Given that influenza vaccine effectiveness depends on a good antigenic match between the vaccine and circulating viruses, it is important to assess the antigenic properties of newly emerging variants continuously. With the increasing application of r...

Ultrasound-based classification of follicular thyroid Cancer using deep convolutional neural networks with transfer learning.

Scientific reports
This study aimed to develop and validate convolutional neural network (CNN) models for distinguishing follicular thyroid carcinoma (FTC) from follicular thyroid adenoma (FTA). Additionally, this current study compared the performance of CNN models wi...

MEN: leveraging explainable multimodal encoding network for precision prediction of CYP450 inhibitors.

Scientific reports
Drug-drug interactions (DDIs) present serious risks in clinical settings, especially for patients who are prescribed multiple medications. A major factor contributing to these interactions is the inhibition of cytochrome P450 (CYP450) enzymes, which ...

Identification of pyroptosis related genes and subtypes in atherosclerosis using multiomic and single cell analysis.

Scientific reports
Atherosclerosis (AS), the leading cause of cardiovascular diseases, is a chronic inflammatory disorder involving lipid metabolism, immune dysregulation, and cell death. Pyroptosis, a form of inflammatory programmed cell death, is implicated in AS pro...

Prognostic model of lung adenocarcinoma from the perspective of cancer-associated fibroblasts using single-cell and bulk RNA-sequencing.

Scientific reports
Cancer-associated fibroblasts (CAFs) play important roles in the progression of lung adenocarcinoma (LUAD). We examined CAF subgroups via gene ontology, pseudo-time, and cell communication analyses and explored their prognostic value in LUAD using a ...

Personalized azithromycin treatment rules for children with watery diarrhea using machine learning.

Nature communications
We use machine learning to identify innovative strategies to target azithromycin to the children with watery diarrhea who are most likely to benefit. Using data from a randomized trial of azithromycin for watery diarrhea (NCT03130114), we develop per...

A machine learning model using clinical notes to identify physician fatigue.

Nature communications
Clinical notes should capture important information from a physician-patient encounter, but they may also contain signals indicative of physician fatigue. Using data from 129,228 emergency department (ED) visits, we train a model to identify notes wr...