Journal of chemical information and modeling
Dec 8, 2025
The drug discovery process is inherently lengthy, complex, and costly, with high attrition rates driven by safety concerns, limited efficacy, and regulatory barriers. AI-driven computational methods have become crucial in accelerating this process by...
Despite decades of research, the successful clinical translation of intravenously administered nanomedicines is underwhelming. One significant barrier to progress is the opsonization and rapid clearance from the bloodstream due to protein corona form...
Existing artificial tactile sensing technologies face significant challenges in addressing signal instability caused by the complex mechanical responses of soft materials. Here, a multimodal smart tactile finger based on a triboelectric nanogenerator...
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a growing global health challenge. Conventional diagnostic tools have limited sensitivity and specificity for early-stage disease. In this context, long non-coding RNAs (lncRNAs) have emerged as promisin...
Retinitis pigmentosa (RP) and Stargardt Disease (STGD) are inherited retinal diseases that can seriously affect vision. In this study, we present a novel, two-phase self-supervised learning method that addresses the challenge of limited labeled data ...
BACKGROUND: Low back pain imposes a substantial burden on global healthcare systems. Kinesiophobia is highly prevalent among older adults with chronic low back pain, severely hindering effective intervention and treatment. However, current assessment...
Early detection of lung cancer is crucial for improving patient outcomes. However, accurately diagnosing invasive pulmonary nodules and predicting tumor invasiveness remain major clinical challenges. Given the established role of immune dysfunction i...
The main objective of osteoporosis management is to prevent osteoporotic fractures. Using machine learning methods, new risk variables can be identified to enhance the ability to identify women with osteoporosis who are at an increased risk of bone f...
The COVID-19 pandemic has placed immense pressure on global healthcare systems, underscoring the urgent need for early and accurate prediction of disease severity to improve patient care and optimize resource allocation. Failure in ward allocation ca...
The rapid proliferation of AI-generated text from models such as ChatGPT-3.5 and ChatGPT-4 has raised critical challenges in verifying content authenticity and ensuring ethical use of language technologies. This study presents a comprehensive framewo...
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