AIMC Topic: Inflammation

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Divergent Immune Pathways in Coronary Artery Disease and Aortic Stenosis: The Role of Chronic Inflammation and Senescence.

International journal of molecular sciences
Coronary artery disease (CAD) remains a major cause of cardiovascular morbidity and mortality, with growing evidence linking immune dysregulation to its pathogenesis. Aortic stenosis often coexists with CAD (ASCAD), representing an advanced disease f...

Altered aminoacid and lipid metabolism in a rat orofacial inflammation model determined by omics approach: potential role in trigeminal sensitisation.

The journal of headache and pain
BACKGROUND: Trigeminal activation and sensitisation involved in chronic inflammatory orofacial pain share several similarities with headaches, including migraine. Therefore, understanding the pathophysiological mechanisms is important to determine no...

Systemic inflammation mediates the relationship between urinary cadmium and chronic cough risk: findings based on multiple statistical models.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Epidemiological research examining the relationship between urinary cadmium and the risk of chronic cough remains scarce. This study included 2965 participants for a cross-sectional study from the NHANES. The weighted quantile sum (WQS) regression, b...

Deep learning for fetal inflammatory response diagnosis in the umbilical cord.

Placenta
INTRODUCTION: Inflammation of the umbilical cord can be seen as a result of ascending intrauterine infection or other inflammatory stimuli. Acute fetal inflammatory response (FIR) is characterized by infiltration of the umbilical cord by fetal neutro...

Exercise Therapy in Down Syndrome: A Systematic Review and Meta-Analysis Focused on Muscle Strength, Redox Balance, and Inflammatory Profile.

Medicine and science in sports and exercise
OBJECTIVE: This study systematically reviewed and meta-analyzed randomized and quasi-randomized controlled trials investigating the impact of exercise therapy on muscle strength, redox balance, and inflammatory profile in individuals with Down syndro...

Artificial Intelligence-Enabled Quantitative Assessment and Intervention for Heart Inflammation Model Organoids.

Angewandte Chemie (International ed. in English)
Inflammation plays a crucial role in progression of cardiovascular diseases (CVDs); thus, the discovery of rapid and precise analytical tools to assess inflammation related to CVDs is highly desirable for their diagnosis and therapeutic discovery. Ho...

Molecular features and diagnostic modeling of synovium- and IPFP-derived OA macrophages in the inflammatory microenvironment via scRNA-seq and machine learning.

Journal of orthopaedic surgery and research
BACKGROUND: Osteoarthritis (OA) is the leading cause of degenerative joint disease, with total joint replacement as the only definitive cure. However, no disease-modifying therapy is currently available. Inflammation and fibrosis in the infrapatellar...

Machine learning based association between inflammation indicators (NLR, PLR, NPAR, SII, SIRI, and AISI) and all-cause mortality in arthritis patients with hypertension: NHANES 1999-2018.

Frontiers in public health
BACKGROUND: This study aimed to evaluate the relationship between CBC-derived inflammatory markers (NLR, PLR, NPAR, SII, SIRI, and AISI) and all-cause mortality (ACM) risk in arthritis (AR) patients with hypertensive (HTN) using data from the NHANES.

Improved MRI detection of inflammation-induced changes in bone marrow microstructure in mice: a machine learning-enhanced T2 distribution analysis.

European radiology experimental
BACKGROUND: We investigated inflammation-induced changes in femoral hematopoietic bone marrow using advanced magnetic resonance imaging (MRI) techniques, including T2-weighted imaging, scalar T2 mapping, and machine learning-enhanced T2 distribution ...

Infection and Inflammation in Nuclear Medicine Imaging: The Role of Artificial Intelligence.

Seminars in nuclear medicine
Infectious and inflammatory diseases represent a global challenge. Delayed diagnosis and treatment lead to death, disabilities and impairment of the quality of life. The detection of low-grade inflammation and occult infections remains challenging. N...