AIMC Topic: Insulin Resistance
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Improved perfusion pattern score association with type 2 diabetes severity using machine learning pipeline: Pilot study.
Journal of magnetic resonance imaging : JMRI
Aug 5, 2018
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with alterations in the blood-brain barrier, neuronal damage, and arterial stiffness, thus affecting cerebral metabolism and perfusion. There is a need to implement machine-learning methodolog...
Aged, 80 and over
Cross-Sectional Studies
Male
Middle Aged
Severity of Illness Index
Machine Learning
Prospective Studies
Brain
Female
Aged
Magnetic Resonance Imaging
Brain Mapping
Perfusion
Cognition Disorders
Humans
Linear Models
Pilot Projects
Diabetes Mellitus, Type 2
Imaging, Three-Dimensional
Insulin Resistance
Longitudinal Studies
Plasminogen activator inhibitor-1 is associated with the metabolism and development of advanced colonic polyps.
Translational research : the journal of laboratory and clinical medicine
Jun 6, 2018
Implications of plasminogen activator inhibitor-1 (PAI-1) in colonic polyps remain elusive. A prospective study was conducted with 188 consecutive subjects who underwent colonoscopy at a tertiary referral center. Biochemical parameters, serum PAI-1 l...
Fuzzy set-based generalized multifactor dimensionality reduction analysis of gene-gene interactions.
BMC medical genomics
Apr 20, 2018
BACKGROUND: Gene-gene interactions (GGIs) are a known cause of missing heritability. Multifactor dimensionality reduction (MDR) is one of most commonly used methods for GGI detection. The generalized multifactor dimensionality reduction (GMDR) method...
The effect of vitamin D supplementation on insulin resistance, visceral fat and adiponectin in vitamin D deficient women with polycystic ovary syndrome: a randomized placebo-controlled trial.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Dec 22, 2017
INTRODUCTION: Low plasma 25-hydroxy-vitamin D (25OHD) is associated with polycystic ovary syndrome (PCOS). Vitamin D deficiency may contribute to the development of insulin resistance, visceral fat and low level of adiponectin which are common featur...
A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome.
Nutrients
Dec 22, 2017
Since coffee may help to prevent the development of metabolic syndrome (MetS), we aimed to evaluate the short- and long-term effects of a coffee-based supplement on different features of diet-induced MetS. In this study, 24 Sprague Dawley rats were d...
Lipids
Coffea
Non-alcoholic Fatty Liver Disease
Alkaloids
Diterpenes
Caffeic Acids
Carbon-13 Magnetic Resonance Spectroscopy
Disease Models, Animal
Dietary Sucrose
Cytokines
Metabolic Syndrome
Insulin
Animals
Dietary Supplements
Time Factors
Blood Glucose
Liver
Insulin Resistance
Diet, High-Fat
Seeds
Rats, Sprague-Dawley
Effect of a short-term physical activity intervention on liver fat content in obese children.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
Dec 20, 2017
Nonalcoholic fatty liver disease is the most common chronic liver disease and can present with advanced fibrosis or nonalcoholic steatohepatitis. The purpose of this study was to investigate the effect of a 7-day intense physical activity interventio...
Circulating triacylglycerols but not pancreatic fat associate with insulin secretion in healthy humans.
Metabolism: clinical and experimental
Dec 19, 2017
BACKGROUND: Loss of adequate insulin secretion for the prevailing insulin resistance is critical for the development of type 2 diabetes and has been suggested to result from circulating lipids (triacylglycerols [TG] or free fatty acids) and/or adipoc...
Resolution of type 2 diabetes after sleeve gastrectomy: a 2-step hypothesis.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Dec 14, 2017
BACKGROUND: Weight loss (WL) and altered gut hormonal levels are involved in glucose homeostasis after laparoscopic sleeve gastrectomy (LSG).
Putative identification of components in Zengye Decoction and their effects on glucose consumption and lipogenesis in insulin-induced insulin-resistant HepG2 cells.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Dec 12, 2017
Zengye Decoction (ZYD) is a well-known traditional medicine in China used for treating diseases associated with "Yin deficiency" such as diabetes. However, little information is available on its components, pharmacological effects and underlying mech...
Relationship Between Serum Macrophage Migration Inhibitory Factor Level and Insulin Resistance, High-Sensitivity C-Reactive Protein and Visceral Fat Mass in Prediabetes.
The American journal of the medical sciences
Oct 26, 2017
BACKGROUND: Growing evidence suggest that macrophage migration inhibitory factor (MIF) plays a vital role in glucose metabolism. We aimed to ascertain whether MIF levels are altered in subjects with prediabetes and also to determine the relationship ...
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