AIMC Topic: Interleukin-6

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Interleukin-6 and interleukin-8 levels in children with aplastic anemia and its correlation with disease severity and response to immunosuppressive therapy.

Annals of African medicine Jan 1, 2023
BACKGROUND: Aplastic anemia (AA) is an uncommon condition characterized by pancytopenia and hypocellular bone marrow. Interleukin (IL)-6 and IL-8 have been shown to inhibit myelopoiesis and are major mediators of tissue damage. The primary goal of th...
Patient Acuity Treatment Outcome Immunosuppressive Agents Humans Interleukin-8 Interleukin-6 Immunosuppression Therapy Adolescent Anemia, Aplastic Child
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Four Biomarkers-Based Artificial Neural Network Model for Accurate Early Prediction of Bacteremia with Low-level Procalcitonin.

Annals of clinical and laboratory science May 1, 2021
OBJECTIVE: Procalcitonin levels above 2.0 ng/mL are associated with a higher risk of severe sepsis. Bacteremia with procalcitonin levels lower than 2.0 ng/mL has not received much attention, and relevant prediction models are lacking. Herein, a panel...
Retrospective Studies Female Aged Aged, 80 and over Young Adult Bacteria Humans Bacteremia Adult Neural Networks, Computer Procalcitonin Male Interleukin-6 C-Reactive Protein Middle Aged Biomarkers Lactic Acid Case-Control Studies Adolescent
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[Obesity and inflammation in students of a Colombian public university].

Revista de salud publica (Bogota, Colombia) Nov 1, 2020
OBJECTIVE: To describe the relationship between obesity and proinflammatory variables in the student population of the University of Quindío.
Waist Circumference Humans Interleukin-6 Cross-Sectional Studies Inflammation Universities Body Mass Index Obesity Colombia
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Machine Learning Classifier Models Can Identify Acute Respiratory Distress Syndrome Phenotypes Using Readily Available Clinical Data.

American journal of respiratory and critical care medicine Oct 1, 2020
Two distinct phenotypes of acute respiratory distress syndrome (ARDS) with differential clinical outcomes and responses to randomly assigned treatment have consistently been identified in randomized controlled trial cohorts using latent class analys...
Humans Machine Learning Phenotype Age Factors Respiratory Distress Syndrome Randomized Controlled Trials as Topic Tidal Volume Blood Pressure Interleukin-6 Prognosis Biomarkers, Tumor Latent Class Analysis Inflammation Bilirubin Pulmonary Ventilation Vital Signs Serum Albumin Mortality Bicarbonates Creatinine Leukocyte Count Area Under Curve Vasoconstrictor Agents Receptors, Tumor Necrosis Factor, Type I Interleukin-8 Carbon Dioxide Partial Pressure Oxygen Plasminogen Activator Inhibitor 1 Protein C Intercellular Adhesion Molecule-1 Platelet Count
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EVALUATION OF THE BEHAVIOR OF LEVELS OF HMGB1 AND IL6 AS PREDICTORS OF INFECTION, ACUTE KIDNEY INJURY AND MORTALITY IN CIRRHOTIC PATIENTS WITH VARICEAL BLEEDING.

Arquivos de gastroenterologia Jan 1, 2018
BACKGROUND: Gastroesophageal varices and associated bleeding are a major cause of morbidity and mortality in cirrhotic patients.
Biomarkers Acute Kidney Injury Female Male Liver Cirrhosis Middle Aged Humans Predictive Value of Tests Interleukin-6 HMGB1 Protein Prospective Studies Esophageal and Gastric Varices Gastrointestinal Hemorrhage
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[Optimization and evaluation of an inflammatory cell model in LPS-stimulated PMA-differentiated THP-1 cells].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology Nov 1, 2017
Objective To develop an optimal inflammatory cell model from lipopolysaccharide (LPS)-stimulated phorbol ester (PMA)-differentiated THP-1 cells, and investigate its response to anti-inflammatory agent phosphodiesterase inhibitor rolipram. Methods THP...
Inflammation Mediators Tetradecanoylphorbol Acetate Leukemia, Monocytic, Acute Phosphodiesterase 4 Inhibitors Rolipram Humans Cell Differentiation Tumor Necrosis Factor-alpha Anti-Inflammatory Agents Macrophages Models, Biological Interleukin-6 THP-1 Cells Lipopolysaccharides
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[MiR-142-3p inhibits lipopolysaccharide-induced inflammatory response in human periodontal ligament cells through targeting IRAK1].

Shanghai kou qiang yi xue = Shanghai journal of stomatology Dec 1, 2016
PURPOSE: To investigate the effects of miR-142-3p overexpression on secretion of inflammatory factors in human periodontal ligament cells (hPDLCs) induced by lipopolysaccharide (LPS) and its underlying mechanism.
Humans Transfection Interleukin-1 Receptor-Associated Kinases Lipopolysaccharides Cell Line Tumor Necrosis Factor-alpha MicroRNAs Interleukin-6 NF-kappa B Inflammation Periodontal Ligament Signal Transduction
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Dilemma: Correlation Between Serum Level of Hepcidin and IL-6 in Anemic Myeloma Patients.

Medical archives (Sarajevo, Bosnia and Herzegovina) Dec 1, 2016
INTRODUCTION: Anemia occurs in 60% to 80 % of patients with newly diagnosed myeloma multiplex (MM). The cause of anemia in MM is probably multi factorial and involved among the others hepcidin and some cytokines, especially interleukine-6. Anemia in ...
Multiple Myeloma Transferrin Ferritins Hepcidins Hemoglobins Anemia Prognosis Female Aged Aged, 80 and over Adult Sensitivity and Specificity Male Middle Aged Predictive Value of Tests Iron Humans Anti-Infective Agents Interleukin-6 Prospective Studies Biomarkers
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The co-regulators SRC-1 and SMRT are involved in interleukin-6-induced androgen receptor activation.

European cytokine network Nov 1, 2016
BACKGROUND: The androgen receptor (AR) can be stimulated by interleukin-6 (IL-6) in the absence of androgens to induce prostate cancer progression. The purpose of this study was to investigate whether the co-activator steroid receptor coactivator-1 (...
Humans Interleukin-6 Male Cell Line, Tumor Neoplasm Proteins Prostatic Neoplasms Receptors, Androgen Nuclear Receptor Co-Repressor 2 Nuclear Receptor Coactivator 1
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Cerebrospinal fluid ferritin concentration in patients with purulent, bacterial meningitis – own observations.

Przeglad epidemiologiczny Jan 1, 2016
THE AIM: The aim of the study was to evaluate the usefulness of cerebrospinal fluid (CSF) ferritin concentration assessment in adults with purulent, bacterial meningoencephalitis.
Ferritins Humans Meningitis, Bacterial Interleukin-6 Ciliary Neurotrophic Factor Biomarkers Prognosis Meningoencephalitis Female Adult Male Severity of Illness Index
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