AIMC Topic: Intracellular Signaling Peptides and Proteins

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Gasdermin D drives the systemic storm and mortality after trauma with hemorrhage to a greater degree in biological females than males.

Science translational medicine May 28, 2025
Severe injury accompanied by hemorrhagic shock triggers an early release of cell constituents into the circulation, referred to as the systemic storm. The systemic storm drives the systemic inflammatory response and is associated with increased morta...
Humans Hemorrhage Wounds and Injuries Shock, Hemorrhagic Apoptosis Intracellular Signaling Peptides and Proteins Phosphate-Binding Proteins Mice, Inbred C57BL Gasdermins Mice, Knockout Sex Characteristics Sex Factors Female Animals Male Mice
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ULK2 deficiency stratifies autophagy-driven molecular subtypes and exacerbates trophoblasts apoptosis in preeclampsia.

Placenta Apr 18, 2025
INTRODUCTION: Preeclampsia (PE), a placenta-originated hypertensive disorder of pregnancy, lacks targeted therapies despite its significant contribution to maternal and fetal morbidity. Emerging evidence implicates autophagy dysregulation in PE patho...
Humans Pregnancy Female Placenta Autophagy Pre-Eclampsia Adult Trophoblasts Animals Intracellular Signaling Peptides and Proteins Mice Apoptosis Protein Serine-Threonine Kinases
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A morphology and secretome map of pyroptosis.

Molecular biology of the cell Apr 9, 2025
Pyroptosis represents one type of programmed cell death. It is a form of inflammatory cell death that is canonically defined by caspase-1 cleavage and Gasdermin-mediated membrane pore formation. Caspase-1 initiates the inflammatory response (through ...
Phosphate-Binding Proteins Gasdermins Pyroptosis Caspase 1 Humans Intracellular Signaling Peptides and Proteins Leukocytes, Mononuclear Secretome Apoptosis Interleukin-1beta
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Machine learning-based prediction reveals kinase MAP4K4 regulates neutrophil differentiation through phosphorylating apoptosis-related proteins.

PLoS computational biology Mar 17, 2025
Neutrophils, an essential innate immune cell type with a short lifespan, rely on continuous replenishment from bone marrow (BM) precursors. Although it is established that neutrophils are derived from the granulocyte-macrophage progenitor (GMP), the ...
Machine Learning Animals Mice Computational Biology Neutrophils Humans Mice, Knockout Intracellular Signaling Peptides and Proteins Hematopoietic Stem Cells Neutropenia Apoptosis Mice, Inbred C57BL Protein Serine-Threonine Kinases Phosphorylation Cell Differentiation
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Discovery of novel ULK1 inhibitors through machine learning-guided virtual screening and biological evaluation.

Future medicinal chemistry Aug 15, 2024
Build a virtual screening model for ULK1 inhibitors based on artificial intelligence. Build machine learning and deep learning classification models and combine molecular docking and biological evaluation to screen ULK1 inhibitors from 13 million co...
Protein Kinase Inhibitors Intracellular Signaling Peptides and Proteins Autophagy-Related Protein-1 Homolog Humans Machine Learning Molecular Docking Simulation Drug Discovery Molecular Structure Molecular Dynamics Simulation Drug Evaluation, Preclinical
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Understanding and predicting ciprofloxacin minimum inhibitory concentration in Escherichia coli with machine learning.

Scientific reports Sep 14, 2020
It is important that antibiotics prescriptions are based on antimicrobial susceptibility data to ensure effective treatment outcomes. The increasing availability of next-generation sequencing, bacterial whole genome sequencing (WGS) can facilitate a ...
DNA Gyrase Intracellular Signaling Peptides and Proteins Ciprofloxacin Inhibitory Concentration 50 Genes, Bacterial Escherichia coli Proteins Toxicity Tests Anti-Bacterial Agents Drug Resistance, Bacterial Escherichia coli Mutation Machine Learning
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Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.

EMBO molecular medicine Jun 24, 2020
Baricitinib is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI) algorithms, to be useful for COVID-19 infection via proposed anti-c...
Artificial Intelligence Pandemics COVID-19 Cytokines Female SARS-CoV-2 Aged Adult Male Humans COVID-19 Drug Treatment Pyrazoles Protein Kinase Inhibitors Purines Spheroids, Cellular Intracellular Signaling Peptides and Proteins Betacoronavirus Pneumonia, Viral Azetidines Drug Repositioning Middle Aged Leukocytes Antiviral Agents Sulfonamides Liver Drug Evaluation, Preclinical Protein Serine-Threonine Kinases Coronavirus Infections
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Machine learning with autophagy-related proteins for discriminating renal cell carcinoma subtypes.

Scientific reports Jan 20, 2020
Machine learning techniques have been previously applied for classification of tumors based largely on morphological features of tumor cells recognized in H&E images. Here, we tested the possibility of using numeric data acquired from software-based ...
Carcinoma, Renal Cell Intracellular Signaling Peptides and Proteins Autophagy-Related Proteins Autophagy-Related Protein 5 Autophagy-Related Protein-1 Homolog Gene Expression Autophagy Kidney Neoplasms Humans Microtubule-Associated Proteins Machine Learning RNA, Messenger
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FOLFOX treatment response prediction in metastatic or recurrent colorectal cancer patients via machine learning algorithms.

Cancer medicine Jan 1, 2020
Early identification of metastatic or recurrent colorectal cancer (CRC) patients who will be sensitive to FOLFOX (5-FU, leucovorin and oxaliplatin) therapy is very important. We performed microarray meta-analysis to identify differentially expressed ...
Oligonucleotide Array Sequence Analysis Intracellular Signaling Peptides and Proteins Response Evaluation Criteria in Solid Tumors Leucovorin Protein Kinases Datasets as Topic Organoplatinum Compounds Cell Cycle Proteins Gene Expression Profiling Gene Expression Regulation, Neoplastic Antineoplastic Combined Chemotherapy Protocols Neoplasm Recurrence, Local Fluorouracil Humans Machine Learning Prognosis Colorectal Neoplasms Biomarkers, Tumor
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Volumetry of Mesiotemporal Structures Reflects Serostatus in Patients with Limbic Encephalitis.

AJNR. American journal of neuroradiology Nov 14, 2019
BACKGROUND AND PURPOSE: Limbic encephalitis is an autoimmune disease. A variety of autoantibodies have been associated with different subtypes of limbic encephalitis, whereas its MR imaging signature is uniformly characterized by mesiotemporal abnorm...
Female Autoantibodies Humans Intracellular Signaling Peptides and Proteins Adult Glutamate Decarboxylase Machine Learning Male Autoantigens Brain Limbic Encephalitis Middle Aged Neuroimaging Magnetic Resonance Imaging Retrospective Studies
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