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Iodine Radioisotopes

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MRI-based automated detection of implanted low dose rate (LDR) brachytherapy seeds using quantitative susceptibility mapping (QSM) and unsupervised machine learning (ML).

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Dec 1, 2018
BACKGROUND AND PURPOSE: Permanent seed brachytherapy is an established treatment option for localized prostate cancer. Currently, post-implant dosimetry is performed on CT images despite challenging target delineation due to limited soft tissue contr...
Contrast Media Magnetic Resonance Imaging Unsupervised Machine Learning Tomography, X-Ray Computed Male Brachytherapy Radiotherapy Dosage Phantoms, Imaging Prostatic Neoplasms Humans Iodine Radioisotopes
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Prediction of dose to the relatives of patients treated with radioiodine-131 using neural networks.

Journal of radiological protection : official journal of the Society for Radiological Protection Mar 1, 2018
In this study, the effective dose received by the family members and caregivers of 52 thyroid cancer patients, who had been treated with radioiodine I-131, was measured to investigate the ability of the neural network to predict the doses to the rela...
Humans Neural Networks, Computer Radiation Dosage Family Radiation Exposure Caregivers Child Adult Thyroid Neoplasms Middle Aged Iodine Radioisotopes
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Thyroglobulin levels before radioactive iodine therapy and dynamic risk stratification after 1 year in patients with differentiated thyroid cancer.

Archives of endocrinology and metabolism Dec 1, 2017
OBJECTIVES: We sought to assess the relationship between stimulated thyroglobulin (sTg) before radioactive iodine therapy (RIT), and the dynamic risk stratification 1 year after treatment, and to establish the utility of the sTg as a predictor of res...
Adult ROC Curve Adenocarcinoma, Follicular Humans Retrospective Studies Male Treatment Outcome Biomarkers, Tumor Prognosis Carcinoma, Papillary Middle Aged Neoplasm Staging Risk Assessment Iodine Radioisotopes Time Factors Thyroglobulin Thyroid Neoplasms Female
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modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly.

The Journal of biological chemistry Nov 3, 2017
To understand the mechanism for assembly of Lys-linked polyubiquitin degradation signals, we previously demonstrated that the E6AP/UBE3A ligase harbors two functionally distinct E2∼ubiquitin-binding sites: a high-affinity Site 1 required for E6AP Cys...
Ubiquitin Ubiquitination Protein Multimerization Binding Sites Mutagenesis, Site-Directed Ubiquitin-Conjugating Enzymes Isoenzymes Point Mutation Protein Conformation Cysteine Amino Acid Substitution Recombinant Fusion Proteins Ubiquitin-Protein Ligases Iodine Radioisotopes Expert Systems Biocatalysis Humans Computational Biology Molecular Docking Simulation Models, Molecular Cattle Animals
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Doxorubicin enhances (131)I-rituximab induced cell death in Raji cells.

Journal of cancer research and therapeutics Jan 1, 2015
AIM: There are various therapeutic modalities of treatment for non-Hodgkin's lymphoma, but with certain limitations, hence, investigating the scope of combined therapeutic approach.
Blotting, Western Flow Cytometry Doxorubicin Iodine Radioisotopes Humans Radiation-Sensitizing Agents Radiopharmaceuticals Rituximab Signal Transduction Drug Synergism RNA, Messenger Antineoplastic Combined Chemotherapy Protocols Poly(ADP-ribose) Polymerases Tumor Cells, Cultured Cell Proliferation Apoptosis Burkitt Lymphoma
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