AIMC Topic: Iodine Radioisotopes

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MRI-based automated detection of implanted low dose rate (LDR) brachytherapy seeds using quantitative susceptibility mapping (QSM) and unsupervised machine learning (ML).

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Sep 19, 2018
BACKGROUND AND PURPOSE: Permanent seed brachytherapy is an established treatment option for localized prostate cancer. Currently, post-implant dosimetry is performed on CT images despite challenging target delineation due to limited soft tissue contr...
Unsupervised Machine Learning Prostatic Neoplasms Iodine Radioisotopes Brachytherapy Male Contrast Media Magnetic Resonance Imaging Radiotherapy Dosage Phantoms, Imaging Humans Tomography, X-Ray Computed
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Prediction of dose to the relatives of patients treated with radioiodine-131 using neural networks.

Journal of radiological protection : official journal of the Society for Radiological Protection Nov 20, 2017
In this study, the effective dose received by the family members and caregivers of 52 thyroid cancer patients, who had been treated with radioiodine I-131, was measured to investigate the ability of the neural network to predict the doses to the rela...
Iodine Radioisotopes Radiation Dosage Family Caregivers Radiation Exposure Adult Middle Aged Child Thyroid Neoplasms Humans Neural Networks, Computer
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modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly.

The Journal of biological chemistry Sep 18, 2017
To understand the mechanism for assembly of Lys-linked polyubiquitin degradation signals, we previously demonstrated that the E6AP/UBE3A ligase harbors two functionally distinct E2∼ubiquitin-binding sites: a high-affinity Site 1 required for E6AP Cys...
Ubiquitin-Conjugating Enzymes Binding Sites Humans Mutagenesis, Site-Directed Animals Cysteine Ubiquitination Ubiquitin Expert Systems Molecular Docking Simulation Ubiquitin-Protein Ligases Cattle Protein Multimerization Biocatalysis Computational Biology Amino Acid Substitution Isoenzymes Protein Conformation Models, Molecular Recombinant Fusion Proteins Point Mutation Iodine Radioisotopes
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Predicting excellent response to radioiodine in differentiated thyroid cancer using machine learning.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale Aug 1, 2024
OBJECTIVE: If excellent response (ER) occurs after radioactive iodine (RAI) treatment in patients with differentiated thyroid carcinoma (DTC), the recurrence rate is low. Our study aims to predict ER at 6-24 months after RAI by using machine learning...
Humans Machine Learning Retrospective Studies Middle Aged Thyroid Neoplasms Treatment Outcome Iodine Radioisotopes Female Aged Adult Male
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New approach of prediction of recurrence in thyroid cancer patients using machine learning.

Medicine Oct 22, 2021
Although papillary thyroid cancers are known to have a relatively low risk of recurrence, several factors are associated with a higher risk of recurrence, such as extrathyroidal extension, nodal metastasis, and BRAF gene mutation. However, predicting...
Machine Learning Algorithms Prognosis Female Humans Proto-Oncogene Proteins B-raf Tumor Burden Thyroglobulin Thyroid Cancer, Papillary Thyroid Neoplasms Body Mass Index Lymphatic Metastasis Age Factors Neoplasm Recurrence, Local Iodine Radioisotopes Sex Factors Reproducibility of Results Adult Aged Male Young Adult Middle Aged Thyroidectomy
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Thyroglobulin levels before radioactive iodine therapy and dynamic risk stratification after 1 year in patients with differentiated thyroid cancer.

Archives of endocrinology and metabolism Dec 1, 2017
OBJECTIVES: We sought to assess the relationship between stimulated thyroglobulin (sTg) before radioactive iodine therapy (RIT), and the dynamic risk stratification 1 year after treatment, and to establish the utility of the sTg as a predictor of res...
Carcinoma, Papillary Female Middle Aged Humans Thyroid Neoplasms Adult Risk Assessment Iodine Radioisotopes ROC Curve Prognosis Biomarkers, Tumor Time Factors Thyroglobulin Treatment Outcome Retrospective Studies Male Adenocarcinoma, Follicular Neoplasm Staging
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Doxorubicin enhances (131)I-rituximab induced cell death in Raji cells.

Journal of cancer research and therapeutics Jan 1, 2015
AIM: There are various therapeutic modalities of treatment for non-Hodgkin's lymphoma, but with certain limitations, hence, investigating the scope of combined therapeutic approach.
Rituximab Poly(ADP-ribose) Polymerases Burkitt Lymphoma Radiation-Sensitizing Agents Humans Iodine Radioisotopes RNA, Messenger Drug Synergism Cell Proliferation Tumor Cells, Cultured Blotting, Western Flow Cytometry Radiopharmaceuticals Doxorubicin Signal Transduction Antineoplastic Combined Chemotherapy Protocols Apoptosis
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