AIMC Topic: Keratinocytes
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Leveraging autoencoder models and data augmentation to uncover transcriptomic diversity of gingival keratinocytes in single cell analysis.
Scientific reports
Jul 1, 2025
Periodontitis, a chronic inflammatory condition of the periodontium, is associated with over 60 systemic diseases. Despite advancements, precision medicine approaches have had limited success, emphasizing the need for deeper insights into cellular su...
Development of machine learning models for the prediction of the skin sensitization potential of cosmetic compounds.
PeerJ
Dec 13, 2024
BACKGROUND: To enhance the accuracy of allergen detection in cosmetic compounds, we developed a co-culture system that combines HaCaT keratinocytes (transfected with a luciferase plasmid driven by the AKR1C2 promoter) and THP-1 cells for machine lear...
Artificial Intelligence in Dermatology: A Systematic Review of Its Applications in Melanoma and Keratinocyte Carcinoma Diagnosis.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
May 9, 2024
BACKGROUND: Limited access to dermatologic care may pose an obstacle to the early detection and intervention of cutaneous malignancies. The role of artificial intelligence (AI) in skin cancer diagnosis may alleviate potential care gaps.
Non-invasive scoring of cellular atypia in keratinocyte cancers in 3D LC-OCT images using Deep Learning.
Scientific reports
Jan 10, 2022
Diagnosis based on histopathology for skin cancer detection is today's gold standard and relies on the presence or absence of biomarkers and cellular atypia. However it suffers drawbacks: it requires a strong expertise and is time-consuming. Moreover...
Development of quantitative model of a local lymph node assay for evaluating skin sensitization potency applying machine learning CatBoost.
Regulatory toxicology and pharmacology : RTP
Jul 24, 2021
The estimated concentrations for a stimulation index of 3 (EC3) in murine local lymph node assay (LLNA) is an important quantitative value for determining the strength of skin sensitization to chemicals, including cosmetic ingredients. However, anima...
Label-free quality control and identification of human keratinocyte stem cells by deep learning-based automated cell tracking.
Stem cells (Dayton, Ohio)
Mar 30, 2021
Stem cell-based products have clinical and industrial applications. Thus, there is a need to develop quality control methods to standardize stem cell manufacturing. Here, we report a deep learning-based automated cell tracking (DeepACT) technology fo...
Protective effect of polysaccharide from Sophora japonica L. flower buds against UVB radiation in a human keratinocyte cell line (HaCaT cells).
Journal of photochemistry and photobiology. B, Biology
Dec 5, 2018
Natured botanical extract has attracted considerable attention recently in the field of skin anti-ultraviolet (UV) radiation. As a medicinal herb, Sophora japonica flower buds contained several components such as flavonoids, isoflavonoids, triterpene...
Design and synthesis of cell selective α/β-diastereomeric peptidomimetic with potent in vivo antibacterial activity against methicillin resistant S. Aureus.
Bioorganic chemistry
Dec 26, 2017
Design of therapeutically viable antimicrobial peptides with cell selectivity against microorganisms is an important step towards the development of new antimicrobial agents. Here, we report four de novo designed, short amphipathic sequences based on...
Pseudomonas aeruginosa
Humans
Keratinocytes
Enterococcus faecalis
Anti-Bacterial Agents
Erythrocytes
Peptidomimetics
Escherichia coli
Phosphatidylcholines
Female
Acinetobacter baumannii
Methicillin-Resistant Staphylococcus aureus
Phosphatidylglycerols
Animals
Mice, Inbred BALB C
Hemolysis
Stereoisomerism
Microbial Sensitivity Tests
Amino Acid Sequence
Lipid Bilayers
Dermatologist-level classification of skin cancer with deep neural networks.
Nature
Jan 25, 2017
Skin cancer, the most common human malignancy, is primarily diagnosed visually, beginning with an initial clinical screening and followed potentially by dermoscopic analysis, a biopsy and histopathological examination. Automated classification of ski...
Cellular level robotic surgery: Nanodissection of intermediate filaments in live keratinocytes.
Nanomedicine : nanotechnology, biology, and medicine
Sep 6, 2014
We present the nanosurgery on the cytoskeleton of live cells using AFM based nanorobotics to achieve adhesiolysis and mimic the effect of pathophysiological modulation of intercellular adhesion. Nanosurgery successfully severs the intermediate filame...
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