Integrative biology : quantitative biosciences from nano to macro
Jul 20, 2015
Complex carbohydrates are rapidly becoming excellent biomarker candidates because of their high sensitivity to pathological changes. However, the discovery of clinical glycobiomarkers has been slow, due to the scarcity of high-throughput glycoanalyti...
In this study, nanosuspension of stable iodine ((127)I) was prepared by nanoprecipitation process in microfluidic devices. Then, size of particles was optimized using artificial neural networks (ANNs) modeling. The size of prepared particles was eval...
Osteosarcoma (OS) calls for early diagnosis to significantly improve patient survival rates. Exosomes hold significant potential as noninvasive biomarkers for the early diagnosis of cancer. Here, we design a microfluidic device to purify and analyze ...
Probing the viscosity of human aqueous humor is crucial for optimizing micro-tube shunts in glaucoma treatment. However, conventional viscometers are not suitable for aqueous humor due to the limited sample volume-only tens of microliters-that can be...
Preventing waterborne disease caused by bacteria is especially important in low-resource settings, where skilled personnel and laboratory equipment are scarce. This work reports a straightforward method for classifying bacterial species by monitoring...
Hepatitis C virus (HCV) infection is a severe public health problem affecting nearly 3% of the world population. Of those affected, approximately 80% develop chronic infections. Initiating treatment through HCV RNA testing remains challenging, especi...
Approximately 70% of breast cancer (BC) diagnoses are estrogen receptor positive (ER) with ∼40% of ER BC patients presenting resistance to endocrine therapy (ET). Recent studies identify the tumor microenvironment (TME) as having a key role in endoc...
Heart-on-a-chip (HOC) platforms play a pivotal role in cardiac research, yet existing models suffer from mechanical mismatch between the soft myocardial tissue, sensors, and substrate, leading to impaired myocardial function and compromised data capt...
The complex interplay between tumor cells and clusters with endothelial tissues during metastasis, in particular with regard to the exosomes in mediating intercellular communication, is still not well understood. Here, we develop a tumoral-transendot...
Gastric cancer (GC) is a disease with high mortality rates and remains a central focus in medical research. Efficient enrichment, separation, and precise diagnosis of human gastric cancer (HGC) cells from biological samples are essential for early de...
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