AIMC Topic: Limit of Detection

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Self-primer and self-template recycle rolling circle amplification strategy for sensitive detection of uracil-DNA glycosylase activity.

Analytica chimica acta
Sensitive and accurate detection of uracil-DNA glycosylase (UDG) activity is available for evaluating and validating their function in uracil base-excision repair (UBER) pathway and clinical diagnosis. Here, a sensitive and accurate method for UDG ac...

Self-enhanced PEI-Ru(II) complex with polyamino acid as booster to construct ultrasensitive electrochemiluminescence immunosensor for carcinoembryonic antigen detection.

Analytica chimica acta
In this work, the luminophor tris (4,4'-dicarboxylicacid-2,2'-bipyridyl) ruthenium (II) dichloride (Ru(dcbpy)) was linked to coreactant polyethylenimine (PEI) with effectively shorted distance, forming a novel self-enhanced PEI-Ru(II) complex to fabr...

Nano-biotinylated liposome-based immunoassay for the ultrasensitive detection of protein biomarker in urine.

Talanta
With the development of proteomics and the continuous discovery of biomarkers of trace proteins, it is important to accurately quantify low abundance protein, especially in urine for clinical diagnostics. In this paper, we reported a novel nano-bioti...

Dual-responsive electrochemical immunosensor for detection of insulin based on dual-functional zinc silicate spheres-palladium nanoparticles.

Talanta
In this study, described an electrochemical immunoassay for insulin that is based on the use of zinc silicate spheres loaded with palladium nanoparticles (ZnSiO-PdNPs) that act as dual-function labels. The ZnSiO-PdNPs display high electrocatalytic ac...

Determination of ractopamine and salbutamol in pig hair by liquid chromatography tandem mass spectrometry.

Journal of food and drug analysis
A liquid chromatography tandem mass spectrometric method was developed for the determination of two β-agonists (ractopamine and salbutamol) in pig hair samples. An isotope of ractopamine-d5 or salbutamol-d6 as an internal standard was used to carry o...

Modification-free carbon dots as turn-on fluorescence probe for detection of organophosphorus pesticides.

Food chemistry
It is important to detect pesticides residues due to the concern over food safety. In this work, the burning ash of waste paper was used as carbon source to synthesize carbon dots (C-dots). The fluorescence of obtained C-dots could been turn off by F...

Needle-based sampling coupled with colorimetric reaction catalyzed by layered double hydroxide peroxidase mimic for rapid detection of the change of d-glucose levels with time in bananas.

Analytica chimica acta
For analyte detection in raw fruits, the conventional sample pretreatment method usually involves mashing (blending or homogenization), extraction, and dilution. This process is time-consuming, solvent-intensive and laborious. Usually, there is also ...