AIMC Topic: Liquid Biopsy

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Tumor microenvironment expressed enzymes (Matrix metalloproteinases, cathepsins, urokinase-type plasminogen activator) triggered polymersomes for liquid biopsy and cancer diagnostics: A review.

International journal of biological macromolecules
Enzyme-triggered polymersomes have emerged as a transformative platform in liquid biopsy and cancer diagnostics, enabling high-accuracy biomarker detection through precise enzymatic responsiveness. This review comprehensively examines the rational de...

Lectin-affinity glycosylation pattern analysis of plasma extracellular vesicles: An all-in-one clinical assessment for gastric cancer diagnosis and treatment.

Cancer letters
Extracellular vesicles (EVs) exhibit extensive glycosylation modifications, which are promising biomarkers for gastric cancer (GC). However, EV glycomics and the potential application of EV glycosylation patterns in liquid biopsy remain largely unexp...

AI-powered liquid biopsy for early detection of gastrointestinal cancers.

Clinica chimica acta; international journal of clinical chemistry
Gastrointestinal cancers (GICs) are a leading cause of cancer-related mortality worldwide, largely due to late-stage diagnosis. Liquid biopsy has emerged as a promising non-invasive diagnostic tool, utilizing circulating tumor DNA (ctDNA), circulatin...

The correlation of liquid biopsy genomic data to radiomics in colon, pancreatic, lung and prostatic cancer patients.

European journal of cancer (Oxford, England : 1990)
INTRODUCTION: With the advances in artificial intelligence (AI) and precision medicine, radiomics has emerged as a promising tool in the field of oncology. Radiogenomics integrates radiomics with genomic data, potentially offering a non-invasive meth...

Validation of an AI-enabled exome/transcriptome liquid biopsy platform for early detection, MRD, disease monitoring, and therapy selection for solid tumors.

Scientific reports
Effective clinical management of patients with cancer requires highly accurate diagnosis, precise therapy selection, and highly sensitive monitoring of disease burden. Caris Assure is a multifunctional blood-based assay that couples whole exome and w...

Innovative technologies and their clinical prospects for early lung cancer screening.

Clinical and experimental medicine
BACKGROUND: Lung cancer remains the leading cause of cancer-related mortality worldwide, due to lacking effective early-stage screening approaches. Imaging, such as low-dose CT, poses radiation risk, and biopsies can induce some complications. Additi...

Predicting response to patients with gastric cancer via a dynamic-aware model with longitudinal liquid biopsy data.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
BACKGROUND: Gastric cancer (GC) presents challenges in predicting treatment responses due to its patient-specific heterogeneity. Recently, liquid biopsies have emerged as a valuable data modality, offering essential cellular and molecular insights wh...

Liquid Biopsy: The Challenges of a Revolutionary Approach in Oncology.

International journal of molecular sciences
Liquid biopsy has gained attention in oncology as a non-invasive diagnostic tool, offering valuable insights into tumor biology through the analysis of circulating nucleic acid (cfDNA and cfRNA), circulating tumor cells (CTCs), extracellular vesicles...

Comprehensive assessment of the role of spectral data pre-processing in spectroscopy-based liquid biopsy.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Spectroscopic data often contain artifacts or noise related to the sample characteristics, instrumental variations, or experimental design flaws. Therefore, classifying the raw data is not recommended and might lead to biased results. Nevertheless, m...

Artificial intelligence-driven integration of multi-omics and radiomics: A new hope for precision cancer diagnosis and prognosis.

Biochimica et biophysica acta. Molecular basis of disease
Despite advances in cancer diagnosis and treatment, the disease remains a major health challenge. Integrating multi-omics, radiomics, and artificial intelligence has improved detection, prognosis, and treatment monitoring. Molecular multi-omics provi...