TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
Jul 4, 2025
Trait Genome-to-Phenome (G2P) dimensionality and "breeding context" combine to influence the realised prediction skill of different whole genome prediction (WGP) methods. Theory and empirical evidence both suggest there is likely to be "No Free Lunch...
Kidney transplantation (KT) is an effective treatment for end-stage renal disease; however, the lifelong immunosuppressive regimen increases the risk of infection, presenting significant clinical, and economic challenges. Identifying predictive bioma...
Diabetic kidney disease (DKD) is a serious complication of diabetes patients with long time duration, presenting with albuminuria and/or a reduced estimated glomerular filtration rate (eGFR), and without symptoms of other primary causes of kidney inj...
Journal of chemical information and modeling
Jul 3, 2025
Synthetic monomycoloyl glycerol (MMG) analogs possess robust immunostimulatory activity and are investigated as adjuvants for subunit vaccines in preclinical and clinical studies. These synthetic lipids consist of a glycerol moiety attached to a cory...
BACKGROUND: The pathogenesis of inflammatory bowel disease (IBD) involves complex molecular mechanisms, and achieving clinical remission remains challenging. This study aims to identify IBD-potential biomarkers, analyze their correlation with immune ...
BACKGROUND: This study employed representative data from the U.S. and China to delve into the correlation among migraine prevalence, the triglyceride‒glucose index, a marker of insulin resistance, and the composite indicator of obesity.
BMC medical informatics and decision making
Jul 3, 2025
BACKGROUND: Prompt-based learning involves the additions of prompts (i.e., templates) to the input of pre-trained large language models (PLMs) to adapt them to specific tasks with minimal training. This technique is particularly advantageous in clini...
BMC medical informatics and decision making
Jul 3, 2025
BACKGROUND: Early detection of malnutrition in critically ill patients is crucial for timely intervention and improved clinical outcomes. However, identifying individuals at risk remains challenging due to the complexity and variability of patient co...
BACKGROUND: Coronary Heart Disease (CHD) and Non-Alcoholic Fatty Liver Disease (NAFLD) share overlapping pathogenic mechanisms including adipose tissue dysfunction, insulin resistance, and systemic inflammation mediated by adipokines. However, the sp...
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major global public health concern, and early screening and identification of high-risk populations are critical for reducing the disease burden. Although several studies have explored the...
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