Intrinsically disordered regions within proteins drive specific molecular functions despite lacking a defined structure. Although disordered regions are integral to controlling mRNA stability and translation, the mechanisms underlying these regulator...
Variants of Uncertain Significance (VUS) in genetic testing for hereditary diseases burden patients and clinicians, yet clinical data that could reduce VUS are underutilized due to a lack of scalable strategies. We assessed whether a machine learning...
International journal of biological macromolecules
Apr 23, 2025
This study investigates the potential of chitosan nanoparticles (CNPs) in enhancing the bioavailability and efficacy of Bacopa monnieri extracts, known for their neuroprotective, antioxidant, and anticancer properties. Different concentrations of CNP...
Electroencephalography (EEG) is widely utilized for train driver state detection due to its high accuracy and low latency. However, existing methods for driver status detection rarely use the rich physiological information in EEG to improve detection...
Proceedings of the National Academy of Sciences of the United States of America
Apr 23, 2025
Disease and behavior subtype identification is of significant interest in biomedical research. However, in many settings, subtype discovery is limited by a lack of robust statistical clustering methods appropriate for binary data. Here, we introduce ...
Journal of health, population, and nutrition
Apr 23, 2025
BACKGROUND: Palliative care is a key component of integrated care to improve care quality and reduce hospitalization costs for patients with chronic obstructive pulmonary disease (COPD). This study aims to use machine learning algorithms to create an...
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome, resulting in inconsistent findings across studies. Identifying a core set of genes consistently involved in COPD pathogenesis, independent of patient variability, i...
INTRODUCTION: Tobacco use during pregnancy is a significant public health concern, associated with adverse maternal and neonatal outcomes. Despite its critical importance, comprehensive data on tobacco use among pregnant women in sub-Saharan Africa i...
OBJECTIVE: The aim of this study was to construct interpretable machine learning models to predict the risk of developing delirium in patients with sepsis and to explore the impact of delirium on the 28-day survival rate of patients.
BACKGROUND: Vascular disease in aging populations spans a wide range of disorders including strokes, circulation disorders and hypertension. As individuals age, vascular disorders co-occur and hence exert combined effects. In the present study we int...
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