Stroke affects approximately 12 million individuals annually, necessitating swift diagnosis to avert fatal outcomes. Current hospital imaging protocols often delay treatment, underscoring the need for portable diagnostic solutions. We have investigat...
BACKGROUND: Classical approaches to subgroup analysis in randomised controlled trials (RCTs) to identify heterogeneous treatment effects (HTEs) involve testing the interaction between each pre-specified possible treatment effect modifier and the trea...
Metabolomics : Official journal of the Metabolomic Society
Feb 22, 2025
BACKGROUND: Despite the insights that metabolite analysis can provide into the onset, development, and progression of diseases-thus offering new concepts and methodologies for prevention, diagnosis, and treatment-traditional wet lab experiments are o...
Alzheimer's disease (AD) is the most common cause of dementia, emphasizing the critical need for the development of biomarkers that facilitate accurate and objective assessment of disease progression for early detection and intervention to delay its ...
Untreated neonatal jaundice can have severe consequences. Effective screening for neonatal jaundice can prevent long-term complications in infants. Non-invasive approaches may be beneficial in settings with limited resources. This feasibility study e...
Genomic alterations are the driving force behind pancreatic cancer (PC) tumorigenesis, but they do not fully account for its diverse phenotypes. Investigating the epigenetic landscapes of PC offers a more comprehensive understanding and could identif...
In mental health, accurate symptom assessment and precise measurement of patient conditions are crucial for clinical decision-making and effective treatment planning. Traditional assessment methods can be burdensome, especially for vulnerable populat...
BMC medical informatics and decision making
Feb 22, 2025
BACKGROUND: Post-induction hypotension (PIH) increases surgical complications including myocardial injury, acute kidney injury, delirium, stroke, prolonged hospitalization, and endangerment of the patient's life. Machine learning is an effective tool...
BACKGROUND: Haemorrhagic transformation (HT) is a severe complication after ischaemic stroke, but identifying patients at high risks remains challenging. Although numerous prediction models have been developed for HT following thrombolysis, thrombect...
Aging clinical and experimental research
Feb 22, 2025
BACKGROUND: The accuracy of current tools for predicting adverse events in older inpatients with possible sarcopenia is still insufficient to develop individualized nutrition-related management strategies. The objectives were to develop a machine lea...
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