Clinical cancer research : an official journal of the American Association for Cancer Research
May 15, 2025
PURPOSE: The Cancer Genome Atlas (TCGA) project defined four distinct molecular subtypes of esophagogastric adenocarcinoma: microsatellite instable (MSI), Epstein-Barr virus (EBV)-associated, genomically stable (GS), and chromosomally instable (CIN)....
Changes in the pace of neurodevelopment are key indicators of atypical maturation during early life. Unfortunately, reliable prognostic tools rely on assessments of cognitive and behavioral skills that develop towards the second year of life and afte...
Clinical cancer research : an official journal of the American Association for Cancer Research
May 15, 2025
PURPOSE: The management of chronic lymphocytic leukemia (CLL) has significantly improved with targeted therapies. However, many patients experience a suboptimal response. To optimally select the best therapy, predictive biomarkers are necessary. In t...
Huntington's disease (HD) is a chronic neurodegenerative ailment that affects cognitive decline, motor impairment, and psychiatric symptoms. However, the existing HD detection methods are struggle with limited annotated datasets that restricts their ...
BACKGROUND: Depression associated with Chronic Obstructive Pulmonary Disease (COPD) is a detrimental complication that significantly impairs patients' quality of life. This study aims to develop an online predictive model to estimate the risk of depr...
BACKGROUND: Glioblastoma (GBM) is the most aggressive adult primary brain cancer, characterized by significant heterogeneity, posing challenges for patient management, treatment planning, and clinical trial stratification.
To perform accurate computer vision quality assessments of sperm used within reproductive medicine, a clear separation of each sperm component from the background is critical. This study systematically evaluates and compares the performance of Mask R...
BACKGROUND: Early identification of children at risk of sepsis in emergency departments (EDs) is crucial for timely treatment and improved outcomes. Existing risk scores and criteria for paediatric sepsis are not well-suited for early diagnosis in ED...
BACKGROUND: Neonatal intestinal diseases often have an insidious onset and can lead to poor outcomes if not identified early. Early assessment of abnormal bowel function is critical for timely intervention and improving prognosis, underscoring the cl...
BACKGROUND: The global cancer burden is rapidly increasing, with 20 million new cases estimated in 2022. The world population aged ≥65 years is also increasing, projected to reach 15.9% by 2050, making cancer control for older patients urgent. Surgic...
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