Compound annotation, including the unveiling of dark matter in the metabolomics study represents a pivotal undertaking within the metabolomics field, serving as the linchpin for unraveling the identities and attributes of chemical entities. This narr...
Journal of the American Society for Mass Spectrometry
Sep 3, 2025
Lung cancer metastasis, the leading cause of patient mortality, is driven by circulating tumor cells (CTCs), which act as direct mediators of metastatic spread. To elucidate the metabolic heterogeneity across lung cancer metastatic stages, a panorami...
Diabetes/metabolism research and reviews
Sep 1, 2025
AIMS: We aimed to explore the gut microbial and serum metabolic disturbances associated with the course of type 1 diabetes mellitus (T1DM), and identify potential biomarkers for discriminating T1DM from normoglycemia individuals by machine learning.
Brassicaceae microgreens constitute a novel and promising source of bioactive compounds, such as polyphenols and glucosinolates. In this work, an integrative computational approach was performed to decipher the interaction between bioaccessible micro...
The increasing global demand for herbs and spices in food and nutraceutical industries highlights their key functional benefits, including antioxidant and anti-inflammatory properties. Ensuring authenticity and traceability is essential to counteract...
Cow's milk protein allergy (CMA) is one of the most common food allergies in children worldwide. However, it is still not well understood why certain children outgrow their CMA and others do not. While there is increasing evidence for a link of CMA w...
Expert review of molecular diagnostics
Jul 1, 2025
INTRODUCTION: Accurate prediction of short-term mortality is crucial for optimizing clinical prognosis and providing treatment decisions. Conventional metrics, including physiological indicators, laboratory indexes and scoring systems, suffer from li...
Journal of the American Society for Mass Spectrometry
Jun 4, 2025
Early recognition of septic shock is crucial for improving clinical management and patient outcomes, especially in the emergency department (ED). This study conducted serum metabolomic profiling on ED patients diagnosed with septic shock (n = 32) and...
To study the differences in the urine metabolome between pediatric patients with severe Mycoplasma pneumoniae pneumonia (SMPP) and those with general Mycoplasma pneumoniae pneumonia (GMPP) via non-targeted metabolomics method, and potential biomarker...
International journal of molecular sciences
May 13, 2025
Lung cancer remains the leading cause of cancer-related mortality worldwide, with early detection critical for improving survival rates, yet conventional methods like CT scans often yield high false-positive rates. This study introduces M-GNN, a grap...
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