AIMC Topic: Mice, Inbred C57BL
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Tribulus terrestris L. Extract Alleviates Atherosclerosis by Suppressing TNF-α-Mediated Macrophage Inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Aug 15, 2025
Atherosclerosis (AS) is a major contributor to cardiovascular disease. In traditional Chinese medicine, Tribulus terrestris L., or Baijili (BJL), has shown therapeutic effects on inflammation and cardiovascular issues. Our prior research indicated th...
Nutritionally Responsive PMv DAT Neurons Are Dynamically Regulated During Pubertal Transition.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jul 15, 2025
Pubertal development is tightly regulated by energy balance. The crosstalk between metabolism and reproduction is orchestrated by complex neural networks, and leptin action in the hypothalamus plays a critical role. The ventral premammillary nucleus ...
MACHINE LEARNING AND BIOINFORMATICS TO IDENTIFY COAGULATION BIOMARKERS IN SEPSIS-RELATED KIDNEY INJURY.
Shock (Augusta, Ga.)
Jul 1, 2025
Background: Sepsis-associated acute kidney injury (SA-AKI) is a life-threatening complication with mortality rates exceeding 50%, yet its molecular drivers remain poorly defined. Dysregulated coagulation is increasingly implicated in SA-AKI pathogene...
Unveiling the systemic impact of airborne microplastics: Integrating breathomics and machine learning with dual-tissue transcriptomics.
Journal of hazardous materials
Jun 15, 2025
Airborne microplastics (MPs) pose significant respiratory and systemic health risks upon inhalation; however, current assessment methods remain inadequate. This study integrates breathomics and transcriptomics to establish a non-invasive approach for...
Characterization of ROMK cellular heterogeneity along the mouse kidney thick ascending limb.
Pflugers Archiv : European journal of physiology
Jun 1, 2025
The renal thick ascending limb (TAL) plays a key role in water and ion homeostasis. Apical potassium secretion via the renal outer medullary potassium channel (ROMK) is essential for transepithelial sodium reabsorption via the furosemide-sensitive Na...
Metaplasticity and continual learning: mechanisms subserving brain computer interface proficiency.
Journal of neural engineering
May 23, 2025
Brain computer interfaces (BCIs) require substantial cognitive flexibility to optimize control performance. Remarkably, learning this control is rapid, suggesting it might be mediated by neuroplasticity mechanisms operating on very short time scales....
A circadian behavioral analysis suite for real-time classification of daily rhythms in complex behaviors.
Cell reports methods
May 19, 2025
Long-term analysis of animal behavior has been limited by reliance on real-time sensors or manual scoring. Existing machine learning tools can automate analysis but often fail under variable conditions or ignore temporal dynamics. We developed a scal...
Blood-brain barrier crossing biopolymer targeting c-Myc and anti-PD-1 activate primary brain lymphoma immunity: Artificial intelligence analysis.
Journal of controlled release : official journal of the Controlled Release Society
May 10, 2025
Primary Central Nervous System Lymphoma is an aggressive central nervous system neoplasm with poor response to pharmacological treatment, partially due to insufficient drug delivery across blood-brain barrier. In this study, we developed a novel ther...
ML-UrineQuant: A machine learning program for identifying and quantifying mouse urine on absorbent paper.
Physiological reports
Mar 1, 2025
The void spot assay has gained popularity as a way of assessing functional bladder voiding parameters in mice, but analyzing the size and distribution of urine spot patterns on filter paper with software remains problematic due to inter-laboratory di...
Forestwalk: A Machine Learning Workflow Brings New Insights Into Posture and Balance in Rodent Beam Walking.
The European journal of neuroscience
Mar 1, 2025
The beam walk is widely used to study coordination and balance in rodents. While the task has ethological validity, the main endpoints of "foot slip counts" and "time to cross" are prone to human-rater variability and offer limited sensitivity and sp...
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