AIMC Topic: Mice

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A simple generative model of the mouse mesoscale connectome.

eLife Mar 15, 2016
Recent technological advances now allow for the collection of vast data sets detailing the intricate neural connectivity patterns of various organisms. Oh et al. (2014) recently published the most complete description of the mouse mesoscale connectom...
Connectome Neural Networks, Computer Animals Mice
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Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.

Arteriosclerosis, thrombosis, and vascular biology Mar 10, 2016
OBJECTIVE: Recent genome-wide association studies of coronary artery disease (CAD) have revealed 58 genome-wide significant and 148 suggestive genetic loci. However, the molecular mechanisms through which they contribute to CAD and the clinical impli...
Mice Genomics Genetic Predisposition to Disease Computational Biology Genome-Wide Association Study Humans Protein Interaction Maps Gene Regulatory Networks Neural Networks, Computer Phenotype STAT3 Transcription Factor Genetic Loci Gene Expression Regulation Lumican Signal Transduction Databases, Genetic Bayes Theorem Coronary Artery Disease Computer Simulation Animals Gene Expression Profiling Case-Control Studies
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Multiple classifier systems for automatic sleep scoring in mice.

Journal of neuroscience methods Feb 27, 2016
BACKGROUND: Electroencephalogram (EEG) and electromyogram (EMG) recordings are often used in rodents to study sleep architecture and sleep-associated neural activity. These recordings must be scored to designate what sleep/wake state the animal is in...
Mice Electroencephalography Signal Processing, Computer-Assisted Electromyography Sleep Stages Machine Learning Algorithms Animals
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A neurorobotic platform for locomotor prosthetic development in rats and mice.

Journal of neural engineering Feb 10, 2016
OBJECTIVES: We aimed to develop a robotic interface capable of providing finely-tuned, multidirectional trunk assistance adjusted in real-time during unconstrained locomotion in rats and mice.
Mice, Inbred C57BL Robotics Equipment Design Hindlimb Female Animals Mice Rats Neural Prostheses Locomotion Spinal Cord Injuries Rats, Inbred Lew
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Canonical variate regression.

Biostatistics (Oxford, England) Feb 9, 2016
In many fields, multi-view datasets, measuring multiple distinct but interrelated sets of characteristics on the same set of subjects, together with data on certain outcomes or phenotypes, are routinely collected. The objective in such a problem is o...
Data Interpretation, Statistical Body Weight Supervised Machine Learning Alcoholism Mice Models, Statistical Regression Analysis Humans Algorithms Animals
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Reporting phenotypes in mouse models when considering body size as a potential confounder.

Journal of biomedical semantics Feb 9, 2016
Genotype-phenotype studies aim to identify causative relationships between genes and phenotypes. The International Mouse Phenotyping Consortium is a high throughput phenotyping program whose goal is to collect phenotype data for a knockout mouse stra...
Animals Male Mice Genotype Phenotype Models, Animal Female Reference Standards Gene Ontology Body Size
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Multivariate Calibration Approach for Quantitative Determination of Cell-Line Cross Contamination by Intact Cell Mass Spectrometry and Artificial Neural Networks.

PloS one Jan 28, 2016
Cross-contamination of eukaryotic cell lines used in biomedical research represents a highly relevant problem. Analysis of repetitive DNA sequences, such as Short Tandem Repeats (STR), or Simple Sequence Repeats (SSR), is a widely accepted, simple, a...
Human Embryonic Stem Cells Coculture Techniques Calibration Multivariate Analysis Specimen Handling Mass Spectrometry Cell Line Principal Component Analysis Humans Neural Networks, Computer Animals Mice
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ZeitZeiger: supervised learning for high-dimensional data from an oscillatory system.

Nucleic acids research Jan 26, 2016
Numerous biological systems oscillate over time or space. Despite these oscillators' importance, data from an oscillatory system is problematic for existing methods of regularized supervised learning. We present ZeitZeiger, a method to predict a peri...
Algorithms Animals Gene Expression Profiling Gene Regulatory Networks Mice Computational Biology Supervised Machine Learning Circadian Clocks Time Periodicity
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Protective coatings for intraocular wirelessly controlled microrobots for implantation: Corrosion, cell culture, and in vivo animal tests.

Journal of biomedical materials research. Part B, Applied biomaterials Jan 24, 2016
Diseases in the ocular posterior segment are a leading cause of blindness. The surgical skills required to treat them are at the limits of human manipulation ability, and involve the risk of permanent retinal damage. Instrument tethering and design l...
Implants, Experimental Injections, Intraocular Pyrroles Wireless Technology Gold Female Cobalt Nickel Animals Materials Testing Polymers Mice Rabbits NIH 3T3 Cells Robotics Coated Materials, Biocompatible
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Heat shock protein A12B protects against sepsis-induced impairment in vascular endothelial permeability.

The Journal of surgical research Dec 30, 2015
BACKGROUND: As a common and life-threatening infectious syndrome, sepsis contributes significantly to morbidity and mortality in clinical settings. Vascular endothelial injury and hyperpermeability play an important role in the development of sepsis-...
Escherichia coli Lipopolysaccharides Mice, Inbred C57BL HSP70 Heat-Shock Proteins Blotting, Western Human Umbilical Vein Endothelial Cells Permeability Up-Regulation Endothelium, Vascular Male Sepsis Real-Time Polymerase Chain Reaction Mice Humans Biomarkers Animals
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