AIMC Topic: Mice

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[Astragalus polysaccharide combined with cisplatin inhibits growth of recurrent tumor and down-regulats the expression of CD44, CD62P and osteopontin in tumor tissues in mice bearing Lewis lung cancer].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Objective To investigate the effects of Astragalus polysaccharide (APS) combined with cisplatin (DDP) on the pathological morphology of recurrent tumor and the expression of metastasis-related proteins CD44, CD62P and osteopontin (OPN) following Lewi...

Predicting protein-protein interactions through sequence-based deep learning.

Bioinformatics (Oxford, England)
MOTIVATION: High-throughput experimental techniques have produced a large amount of protein-protein interaction (PPI) data, but their coverage is still low and the PPI data is also very noisy. Computational prediction of PPIs can be used to discover ...

Assessing Deep and Shallow Learning Methods for Quantitative Prediction of Acute Chemical Toxicity.

Toxicological sciences : an official journal of the Society of Toxicology
Animal-based methods for assessing chemical toxicity are struggling to meet testing demands. In silico approaches, including machine-learning methods, are promising alternatives. Recently, deep neural networks (DNNs) were evaluated and reported to ou...

Automated classification of multiphoton microscopy images of ovarian tissue using deep learning.

Journal of biomedical optics
Histopathological image analysis of stained tissue slides is routinely used in tumor detection and classification. However, diagnosis requires a highly trained pathologist and can thus be time-consuming, labor-intensive, and potentially risk bias. He...

A Real-Time Reconfigurable Multichip Architecture for Large-Scale Biophysically Accurate Neuron Simulation.

IEEE transactions on biomedical circuits and systems
Simulation of brain neurons in real-time using biophysically meaningful models is a prerequisite for comprehensive understanding of how neurons process information and communicate with each other, in effect efficiently complementing in-vivo experimen...

ICG: a wiki-driven knowledgebase of internal control genes for RT-qPCR normalization.

Nucleic acids research
Real-time quantitative PCR (RT-qPCR) has become a widely used method for accurate expression profiling of targeted mRNA and ncRNA. Selection of appropriate internal control genes for RT-qPCR normalization is an elementary prerequisite for reliable ex...

Evaluation of (indigenous drug) as oxidative stress down-regulator using serum-free explant culture system.

Indian journal of pharmacology
CONTEXT: The importance of phytochemicals/natural products as potential therapeutic agents in the present context is gaining a lot of importance. India with a rich heritage of such preparations needs evaluation as potent drugs. Explant culture system...