AIMC Topic: Microglia

Clear Filters Showing 11 to 20 of 33 articles

Identification of Disulfidptosis-Related Genes in Ischemic Stroke by Combining Single-Cell Sequencing, Machine Learning Algorithms, and In Vitro Experiments.

Neuromolecular medicine Sep 15, 2024
BACKGROUND: Ischemic stroke (IS) is a severe neurological disorder with a pathogenesis that remains incompletely understood. Recently, a novel form of cell death known as disulfidptosis has garnered significant attention in the field of ischemic stro...
Algorithms Animals Male Humans Machine Learning Nomograms Microglia Ischemic Stroke Cell Death Transcriptome Single-Cell Analysis Mice
View on PubMed DOI

Dynamic changes in pyroptosis following spinal cord injury and the identification of crucial molecular signatures through machine learning and single-cell sequencing.

Journal of pharmaceutical and biomedical analysis Aug 26, 2024
The pathological cascade of spinal cord injury (SCI) is highly intricate. The onset of neuroinflammation can exacerbate the extent of damage. Pyroptosis is a form of inflammation-linked programmed cell death (PCD), the inhibition of pyroptosis can pa...
Single-Cell Analysis Mice Disease Models, Animal Mice, Inbred C57BL Machine Learning Animals Male Pyroptosis Spinal Cord Spinal Cord Injuries Cell Line Neuroinflammatory Diseases Microglia
View on PubMed DOI

Regression convolutional neural network models implicate peripheral immune regulatory variants in the predisposition to Alzheimer's disease.

PLoS computational biology Aug 26, 2024
Alzheimer's disease (AD) involves aggregation of amyloid β and tau, neuron loss, cognitive decline, and neuroinflammatory responses. Both resident microglia and peripheral immune cells have been associated with the immune component of AD. However, th...
Alzheimer Disease Humans Neural Networks, Computer Genetic Predisposition to Disease Computational Biology Microglia Neurons
View on PubMed DOI

Elucidating Microglial Heterogeneity and Functions in Alzheimer's Disease Using Single-cell Analysis and Convolutional Neural Network Disease Model Construction.

Scientific reports Jul 27, 2024
In this study, we conducted an in-depth exploration of Alzheimer's Disease (AD) by integrating state-of-the-art methodologies, including single-cell RNA sequencing (scRNA-seq), weighted gene co-expression network analysis (WGCNA), and a convolutional...
Microglia Alzheimer Disease Humans Neural Networks, Computer Gene Expression Profiling Deep Learning Single-Cell Analysis Gene Regulatory Networks
View on PubMed DOI

Prediction and Interpretation Microglia Cytotoxicity by Machine Learning.

Journal of chemical information and modeling Jul 1, 2024
Ameliorating microglia-mediated neuroinflammation is a crucial strategy in developing new drugs for neurodegenerative diseases. Plant compounds are an important screening target for the discovery of drugs for the treatment of neurodegenerative diseas...
Machine Learning Support Vector Machine Microglia Humans
View on PubMed DOI

Machine learning algorithms integrate bulk and single-cell RNA data to unveil oxidative stress following intracerebral hemorrhage.

International immunopharmacology Jun 11, 2024
BACKGROUND: Increased oxidative stress (OS) activity following intracerebral hemorrhage (ICH) had significantly impacting patient prognosis. Identifying optimal genes associated with OS could enhance the understanding of OS after ICH.
Disease Models, Animal Cerebral Hemorrhage Microglia Mice Monocytes Sequence Analysis, RNA Humans Machine Learning Algorithms Animals Oxidative Stress Male Single-Cell Analysis
View on PubMed DOI

Microglial mediators in autoimmune Uveitis: Bridging neuroprotection and neurotoxicity.

International immunopharmacology May 29, 2024
Autoimmune uveitis, a severe inflammatory condition of the eye, poses significant challenges due to its complex pathophysiology and the critical balance between protective and detrimental immune responses. Central to this balance are microglia, the r...
Animals Neuroprotection Microglia Uveitis Autoimmune Diseases Humans
View on PubMed DOI

A novel deep learning-based method for automatic stereology of microglia cells from low magnification images.

Neurotoxicology and teratology Feb 23, 2024
Microglial cells mediate diverse homeostatic, inflammatory, and immune processes during normal development and in response to cytotoxic challenges. During these functional activities, microglial cells undergo distinct numerical and morphological chan...
Humans Mice Brain Microglia Animals Cell Count Deep Learning
View on PubMed DOI

Anti-inflammatory and antioxidative actions of tacrolimus (FK506) on human microglial HMC3 cell line.

Scandinavian journal of immunology Nov 13, 2023
Microglial cells are indispensable for the normal development and functioning of neurons in the central nervous system, where they play a crucial role in maintaining brain homeostasis by surveilling the microenvironment for signs of injury or stress ...
Anti-Inflammatory Agents Lipopolysaccharides Tacrolimus Humans Clone Cells Neurodegenerative Diseases Cell Line Antioxidants Microglia Inflammation
View on PubMed DOI

E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation in experimental stroke mice.

Journal of ethnopharmacology Oct 30, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatic and medicinal plants continue to be a major component of alternative and traditional medicine in the developing countries. Eucalyptus globulus (Labill.) is being employed to cultivation and production in China...
Infarction, Middle Cerebral Artery Rats DNA-Binding Proteins Inflammation NLR Family, Pyrin Domain-Containing 3 Protein Microglia Lipopolysaccharides Rats, Sprague-Dawley Pyroptosis NF-kappa B Anti-Infective Agents Plant Leaves Interleukin-6 Stroke Anti-Inflammatory Agents Tumor Necrosis Factor-alpha Neuroinflammatory Diseases Animals Mice
View on PubMed DOI
Popular Topics
Recent Journals