AIMC Topic: Microglia

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Machine learning algorithms integrate bulk and single-cell RNA data to unveil oxidative stress following intracerebral hemorrhage.

International immunopharmacology Jun 11, 2024
BACKGROUND: Increased oxidative stress (OS) activity following intracerebral hemorrhage (ICH) had significantly impacting patient prognosis. Identifying optimal genes associated with OS could enhance the understanding of OS after ICH.
Algorithms Animals Male Oxidative Stress Humans Machine Learning Sequence Analysis, RNA Disease Models, Animal Cerebral Hemorrhage Microglia Single-Cell Analysis Mice Monocytes
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Microglial mediators in autoimmune Uveitis: Bridging neuroprotection and neurotoxicity.

International immunopharmacology May 29, 2024
Autoimmune uveitis, a severe inflammatory condition of the eye, poses significant challenges due to its complex pathophysiology and the critical balance between protective and detrimental immune responses. Central to this balance are microglia, the r...
Animals Neuroprotection Humans Microglia Uveitis Autoimmune Diseases
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A novel deep learning-based method for automatic stereology of microglia cells from low magnification images.

Neurotoxicology and teratology Feb 23, 2024
Microglial cells mediate diverse homeostatic, inflammatory, and immune processes during normal development and in response to cytotoxic challenges. During these functional activities, microglial cells undergo distinct numerical and morphological chan...
Humans Mice Cell Count Brain Microglia Animals Deep Learning
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Anti-inflammatory and antioxidative actions of tacrolimus (FK506) on human microglial HMC3 cell line.

Scandinavian journal of immunology Nov 13, 2023
Microglial cells are indispensable for the normal development and functioning of neurons in the central nervous system, where they play a crucial role in maintaining brain homeostasis by surveilling the microenvironment for signs of injury or stress ...
Anti-Inflammatory Agents Tacrolimus Clone Cells Humans Neurodegenerative Diseases Antioxidants Lipopolysaccharides Inflammation Cell Line Microglia
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E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation in experimental stroke mice.

Journal of ethnopharmacology Oct 30, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatic and medicinal plants continue to be a major component of alternative and traditional medicine in the developing countries. Eucalyptus globulus (Labill.) is being employed to cultivation and production in China...
Stroke Inflammation Infarction, Middle Cerebral Artery Rats, Sprague-Dawley DNA-Binding Proteins Plant Leaves Lipopolysaccharides NF-kappa B Tumor Necrosis Factor-alpha Animals NLR Family, Pyrin Domain-Containing 3 Protein Neuroinflammatory Diseases Anti-Infective Agents Anti-Inflammatory Agents Interleukin-6 Pyroptosis Mice Microglia Rats
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Image processing and supervised machine learning for retinal microglia characterization in senescence.

Methods in cell biology Jan 28, 2023
The process of senescence impairs the function of cells and can ultimately be a key factor in the development of disease. With an aging population, senescence-related diseases are increasing in prevalence. Therefore, understanding the mechanisms of c...
Mice Microglia Retina Supervised Machine Learning Animals Aging Image Processing, Computer-Assisted
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Automated characterisation of microglia in ageing mice using image processing and supervised machine learning algorithms.

Scientific reports Feb 2, 2022
The resident macrophages of the central nervous system, microglia, are becoming increasingly implicated as active participants in neuropathology and ageing. Their diverse and changeable morphology is tightly linked with functions they perform, enabli...
Animals Male Aging Image Processing, Computer-Assisted Brain Microscopy Mice, Inbred C57BL Mice Microglia Support Vector Machine Cellular Senescence Age Factors
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Development of deep learning models for microglia analyses in brain tissue using DeePathology™ STUDIO.

Journal of neuroscience methods Sep 27, 2021
BACKGROUND: Interest in artificial intelligence-driven analysis of medical images has seen a steep increase in recent years. Thus, our paper aims to promote and facilitate the use of this state-of-the-art technology to fellow researchers and clinicia...
Mice Microglia Animals Deep Learning Image Processing, Computer-Assisted Artificial Intelligence Brain
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Unified AI framework to uncover deep interrelationships between gene expression and Alzheimer's disease neuropathologies.

Nature communications Sep 10, 2021
Deep neural networks (DNNs) capture complex relationships among variables, however, because they require copious samples, their potential has yet to be fully tapped for understanding relationships between gene expression and human phenotypes. Here we...
Microglia Alzheimer Disease Sex Factors Cohort Studies RNA-Seq Mice Datasets as Topic Gene Expression Regulation Brain Female Aged Male Deep Learning Aged, 80 and over Animals Humans
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Deep learning assisted quantitative assessment of histopathological markers of Alzheimer's disease and cerebral amyloid angiopathy.

Acta neuropathologica communications Aug 21, 2021
Traditionally, analysis of neuropathological markers in neurodegenerative diseases has relied on visual assessments of stained sections. Resulting semiquantitative scores often vary between individual raters and research centers, limiting statistical...
Deep Learning Microglia Astrocytes Humans Neural Networks, Computer Alzheimer Disease Brain Cerebral Amyloid Angiopathy
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