AIMC Topic: Middle Aged

Clear Filters Showing 991 to 1000 of 15877 articles

Autophagy crosstalk with the immune microenvironment in chronic myeloid leukemia and serves as a biomarker for diagnosis and progression.

Frontiers in immunology May 28, 2025
BACKGROUND: Previous studies have shown that autophagy is closely related to the occurrence, development, and treatment resistance of chronic myeloid leukemia (CML) and has dual roles in promoting cell survival and inducing cell death.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Autophagy-Related Proteins Male Middle Aged Disease Progression Autophagy Humans Machine Learning Female Tumor Microenvironment Biomarkers, Tumor
View on PubMed DOI

Advanced predictive modeling for enhanced mortality prediction in ICU stroke patients using clinical data.

PloS one May 28, 2025
Background Stroke is second-leading cause of disability and death among adults. Approximately 17 million people suffer from a stroke annually, with about 85% being ischemic strokes. Predicting mortality of ischemic stroke patients in intensive care u...
Humans Databases, Factual Middle Aged Deep Learning Hospital Mortality Ischemic Stroke Stroke Intensive Care Units Female Aged Male
View on PubMed DOI

The risk factors for relapse behavior in individuals with substance use disorders: An interpretable machine learning study.

Journal of affective disorders May 27, 2025
BACKGROUND: Substance abuse has become a serious public health problem worldwide, and finding effective prevention and treatment strategies is undoubtedly an urgent need. This study addresses the risk factors that lead to relapse behaviors among subs...
Substance-Related Disorders Young Adult Recurrence Humans Adult Machine Learning Male Female Middle Aged Risk Factors
View on PubMed DOI

Hemoglobin - to - red cell distribution width ratio in depression symptoms: Threshold effects and metabolic - inflammatory mediation revealed by multimodal machine learning and symptom network analysis in 196,260 adults.

Journal of affective disorders May 27, 2025
OBJECTIVE: To investigate the association between hemoglobin to red blood cell distribution width ratio (HRR) and depression symptoms.
Hemoglobins Humans Erythrocyte Indices Machine Learning Female Middle Aged Aged Depression Inflammation Body Mass Index Adult Male
View on PubMed DOI

Machine learning models of depression in middle-aged and older adults with cardiovascular metabolic diseases.

Journal of affective disorders May 27, 2025
BACKGROUND: The incidence of cardiovascular metabolic diseases (CMD) is increasing, and depression in CMD patients significantly impacts prognosis. Therefore, this study aimed to develop and validate a predictive model for depression in CMD patients ...
Depressive Disorder Humans Middle Aged Machine Learning China Female Depression Aged Longitudinal Studies Male Cardiovascular Diseases
View on PubMed DOI

Functional connectome-based predictive modeling of suicidal ideation.

Journal of affective disorders May 27, 2025
Suicide represents an egregious threat to society despite major advancements in medicine, in part due to limited knowledge of the biological mechanisms of suicidal behavior. We apply a connectome predictive modeling machine learning approach to ident...
Male Middle Aged Depressive Disorder, Major Adolescent Suicidal Ideation Magnetic Resonance Imaging Connectome Neural Pathways Female Aged Nerve Net Young Adult Adult Humans Machine Learning Brain
View on PubMed DOI

Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy.

EBioMedicine May 27, 2025
BACKGROUND: The impact of high body mass index (BMI) states and associated proteomic factors on brain ageing and Alzheimer's disease (AD) remains unclear.
Alzheimer Disease Neuroimaging Atrophy Male Female Aging Aged Middle Aged Aged, 80 and over Proteomics Radiomics Proteome Humans Body Mass Index Magnetic Resonance Imaging Obesity Biomarkers Brain
View on PubMed DOI

Automatic identification of Parkinsonism using clinical multi-contrast brain MRI: a large self-supervised vision foundation model strategy.

EBioMedicine May 27, 2025
BACKGROUND: Valid non-invasive biomarkers for Parkinson's disease (PD) and Parkinson-plus syndrome (PPS) are urgently needed. Based on our recent self-supervised vision foundation model the Shift Window UNET TRansformer (Swin UNETR), which uses clini...
Male Middle Aged ROC Curve Image Processing, Computer-Assisted Magnetic Resonance Imaging Parkinson Disease Parkinsonian Disorders Neural Networks, Computer Brain Female Aged Humans
View on PubMed DOI

Rapid diagnosis of TERT promoter mutation using Terahertz absorption spectroscopy in glioblastoma.

Scientific reports May 27, 2025
Glioblastoma (GBM) is a highly aggressive brain tumor with poor outcomes and limited treatment options. The telomerase reverse transcriptase (TERT) promoter mutation, one of the key biomarkers in GBM, is linked to tumor progression and prognosis. Thi...
Middle Aged ROC Curve Principal Component Analysis Glioblastoma Female Biomarkers, Tumor Brain Neoplasms Male Mutation Promoter Regions, Genetic Telomerase Terahertz Spectroscopy Humans
View on PubMed DOI

Dual-energy CT combined with histogram parameters in the assessment of perineural invasion in colorectal cancer.

International journal of colorectal disease May 27, 2025
PURPOSE: The purpose is to evaluate the predictive value of dual-energy CT (DECT) combined with histogram parameters and a clinical prediction model for perineural invasion (PNI) in colorectal cancer (CRC).
Humans Retrospective Studies Tomography, X-Ray Computed Female Neoplasm Invasiveness Multivariate Analysis Peripheral Nerves Middle Aged ROC Curve Logistic Models Support Vector Machine Aged Adult Colorectal Neoplasms Male
View on PubMed DOI
Popular Topics
Recent Journals