AIMC Topic: Middle Aged

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Proteomic-based biomarker discovery reveals panels of diagnostic biomarkers for early identification of heart failure subtypes.

Journal of translational medicine
BACKGROUND: Limited access to echocardiography can delay the diagnosis of suspected heart failure (HF), which in turn postpones the initiation of optimal guideline-directed medical therapy. Although natriuretic peptides like B-type natriuretic peptid...

Tumor budding and poorly differentiated clusters as a biological continuum in colorectal cancer invasion and prognosis.

Scientific reports
Tumor budding (TB) and poorly differentiated clusters (PDCs) are features of infiltrative growth patterns and powerful independent prognostic factors in colorectal cancer (CRC), yet the underlying biological mechanisms behind their role in CRC invasi...

Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets.

Nature communications
Coronary artery disease (CAD) is a leading cause of death globally. Antiplatelet therapy remains crucial in preventing and treating CAD-associated thrombotic complications, but it concurrently amplifies the risk of bleeding. Unfortunately, traditiona...

Predicting Immunotherapy Response in Unresectable Hepatocellular Carcinoma: A Comparative Study of Large Language Models and Human Experts.

Journal of medical systems
Hepatocellular carcinoma (HCC) is an aggressive cancer with limited biomarkers for predicting immunotherapy response. Recent advancements in large language models (LLMs) like GPT-4, GPT-4o, and Gemini offer the potential for enhancing clinical decisi...

DEVELOPMENT AND VALIDATION OF A PREDICTION MODEL FOR SEPTIC SHOCK-ASSOCIATED ACUTE KIDNEY INJURY: A MULTICENTER STUDY USING NOMOGRAM MODELING.

Shock (Augusta, Ga.)
Background: Septic shock-associated acute kidney injury (SS-AKI) is a severe complication with high mortality. This study aimed to investigate the risk factors associated with AKI in patients with septic shock and establish a nomogram to predict its ...

Circulating fibroblast growth factor 21 is associated with blood pressure in the Chinese population: a community-based study.

Annals of medicine
BACKGROUND: Our research team previously found that fibroblast growth factor (FGF) 21, a circulating hormone, was significantly associated with atherosclerosis in human and animal models. The relationship between FGF21 and blood pressure (BP) is rare...

A comparative analysis of logistic regression (LR) and artificial neural network (ANN) models for predicting antimicrobial resistance in surgical ICU patients: Insights from real-world evidence in India.

The International journal of risk & safety in medicine
BackgroundMachine learning approaches for the prediction of antimicrobial resistance (AMR) are gaining attention but are yet to be commonly applied in practice.ObjectiveThis study aims to predict the AMR in surgical intensive care unit patients using...

Development of a chitosanase 3-like protein 1 assay kit and study of its application in patients with hepatocellular carcinoma.

BMC biotechnology
OBJECTIVE: The detection kit for plasma Chitinase-3-like Protein 1 was developed using the magnetic bead chemiluminescence method, in order to investigate the diagnostic value of DD, FDP, CHI3L1, AFP-L3 and PIVKA-II in hepatocellular carcinoma.

Reinforcement Learning-Driven Path Generation for Ankle Rehabilitation Robot Using Musculoskeletal-Informed Energy Optimization.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
In rehabilitation robotics, optimizing energy consumption and high interaction forces is essential to prevent unnecessary muscle fatigue and excessive joint loading as they often cause an inefficient trajectory planning and disrupt natural movement p...