AIMC Topic: Multiomics
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Multi-Omics Analysis of the virulence factors and designing of next-generation multi-epitopes Vaccines against Rickettsia prowazekii: a computer-aided vaccine designing approach.
Journal of computer-aided molecular design
May 26, 2025
Rickettsia is a genus of bacteria that are obligate intracellular parasites and are responsible for the febrile diseases known collectively as Rickettsioses. The emergence of antibiotic resistance is an escalating concern and thus developing a vaccin...
Multiomics in Renal Cell Carcinoma: Current Landscape and Future Directions for Precision Medicine.
Current urology reports
May 26, 2025
PURPOSE OF REVIEW: Renal cell carcinoma (RCC) is a prevalent and increasingly diagnosed malignancy associated with high mortality and recurrence rates. Traditional diagnostic and therapeutic approaches have limitations due to the disease's molecular ...
MultiOmicsAgent: Guided Extreme Gradient-Boosted Decision Trees-Based Approaches for Biomarker-Candidate Discovery in Multiomics Data.
Journal of proteome research
May 25, 2025
MultiOmicsAgent (MOAgent) is an innovative, Python-based open-source tool for biomarker discovery, utilizing machine learning techniques, specifically extreme gradient-boosted decision trees, to process multiomics data. With its cross-platform compat...
Development and validation of a multi-omics hemorrhagic transformation model based on hyperattenuated imaging markers following mechanical thrombectomy.
Scientific reports
May 23, 2025
This study aimed to develop a predictive model integrating clinical, radiomics, and deep learning (DL) features of hyperattenuated imaging markers (HIM) from computed tomography scans immediately following mechanical thrombectomy (MT) to predict hemo...
Brassica microgreens shape gut microbiota and functional metabolite profiles in a species-related manner: A multi-omics approach following in vitro gastrointestinal digestion and large intestine fermentation.
Microbiological research
May 19, 2025
Brassicaceae microgreens constitute a novel and promising source of bioactive compounds, such as polyphenols and glucosinolates. In this work, an integrative computational approach was performed to decipher the interaction between bioaccessible micro...
Recent advances in omics and the integration of multi-omics in osteoarthritis research.
Arthritis research & therapy
May 3, 2025
Osteoarthritis (OA) is a complex disorder driven by the combination of environmental and genetic factors. Given its high global prevalence and heterogeneity, developing effective and personalized treatment methods is crucial. This requires identifyin...
Clinical Validation of a Noninvasive Multi-Omics Method for Multicancer Early Detection in Retrospective and Prospective Cohorts.
The Journal of molecular diagnostics : JMD
Apr 29, 2025
Recent studies highlight the promise of blood-based multicancer early detection (MCED) tests for identifying asymptomatic patients with cancer. However, most focus on a single cancer hallmark, thus limiting effectiveness because of cancer's heterogen...
Machine Learning-Based Radiomics in Malignancy Prediction of Pancreatic Cystic Lesions: Evidence from Cyst Fluid Multi-Omics.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Apr 28, 2025
The malignant potential of pancreatic cystic lesions (PCLs) varies dramatically, leading to difficulties when making clinical decisions. This study aimed to develop noninvasive clinical-radiomic models using preoperative CT images to predict the mali...
Leveraging TME features and multi-omics data with an advanced deep learning framework for improved Cancer survival prediction.
Scientific reports
Apr 24, 2025
Glioma, a malignant intracranial tumor with high invasiveness and heterogeneity, significantly impacts patient survival. This study integrates multi-omics data to improve prognostic prediction and identify therapeutic targets. Using single-cell data ...
Identification of pivotal genes and regulatory networks associated with SAH based on multi-omics analysis and machine learning.
Scientific reports
Apr 24, 2025
Subarachnoid hemorrhage (SAH) is a disease with high mortality and morbidity, and its pathophysiology is complex but poorly understood. To investigate the potential therapeutic targets post-SAH, the SAH-related feature genes were screened by the comb...
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