AIMC Topic: Myocytes, Cardiac
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Clinical Significance of Circulating Cardiomyocyte-Specific Cell-Free DNA in Patients With Heart Failure: A Proof-of-Concept Study.
The Canadian journal of cardiology
Oct 19, 2019
We investigated clinical significance of cell-free DNA (cfDNA) in heart failure. This study enrolled 32 heart failure patients and 28 control subjects. Total cfDNA levels were not different between groups (P = 0.343). Bisulfite-digital polymerase cha...
Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival.
Journal of the American Heart Association
Oct 16, 2019
Background Small molecule kinase inhibitors (KIs) are a class of agents currently used for treatment of various cancers. Unfortunately, treatment of cancer patients with some of the KIs is associated with cardiotoxicity, and there is an unmet need fo...
DeepNEU: cellular reprogramming comes of age - a machine learning platform with application to rare diseases research.
Orphanet journal of rare diseases
Jan 10, 2019
BACKGROUND: Conversion of human somatic cells into induced pluripotent stem cells (iPSCs) is often an inefficient, time consuming and expensive process. Also, the tendency of iPSCs to revert to their original somatic cell type over time continues to ...
Detection of genetic cardiac diseases by Ca transient profiles using machine learning methods.
Scientific reports
Jun 19, 2018
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have revolutionized cardiovascular research. Abnormalities in Ca transients have been evident in many cardiac disease models. We have shown earlier that, by exploiting computation...
Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical- Approach Combining Experiments and Machine Learning.
Frontiers in immunology
Mar 20, 2018
Life-threatening cardiomyopathy is a severe, but common, complication associated with severe trauma or sepsis. Several signaling pathways involved in apoptosis and necroptosis are linked to trauma- or sepsis-associated cardiomyopathy. However, the un...
Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools.
Computational and mathematical methods in medicine
Jan 4, 2018
Human heart electrophysiology is complex biological phenomenon, which is indirectly assessed by the measured ECG signal. ECG trace is further analyzed to derive interpretable surrogates including QT interval, QRS complex, PR interval, and T wave morp...
Anti-Arrhythmia Agents
Calcium
Arrhythmias, Cardiac
Ions
Models, Statistical
Regression Analysis
Heart
Potassium
Clinical Trials as Topic
Cell Membrane
Risk
Electrophysiology
Sodium
Programming Languages
Myocytes, Cardiac
Observer Variation
Humans
Artificial Intelligence
Software
Algorithms
Reproducibility of Results
Electrocardiography
Action Potentials
Terfenadine
Development of models for predicting Torsade de Pointes cardiac arrhythmias using perceptron neural networks.
BMC bioinformatics
Dec 28, 2017
BACKGROUND: Blockage of some ion channels and in particular, the hERG (human Ether-a'-go-go-Related Gene) cardiac potassium channel delays cardiac repolarization and can induce arrhythmia. In some cases it leads to a potentially life-threatening arrh...
Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification.
Stem cell reports
Oct 12, 2017
Accurately predicting cardioactive effects of new molecular entities for therapeutics remains a daunting challenge. Immense research effort has been focused toward creating new screening platforms that utilize human pluripotent stem cell (hPSC)-deriv...
Kinase inhibitor screening using artificial neural networks and engineered cardiac biowires.
Scientific reports
Sep 18, 2017
Kinase inhibitors are often used as cancer targeting agents for their ability to prevent the activation of cell growth and proliferation signals. Cardiotoxic effects have been identified for some marketed kinase inhibitors that were not detected duri...
Cardiac Muscle-cell Based Actuator and Self-stabilizing Biorobot - PART 1.
Journal of visualized experiments : JoVE
Jul 11, 2017
Biological machines often referred to as biorobots, are living cell- or tissue-based devices that are powered solely by the contractile activity of living components. Due to their inherent advantages, biorobots are gaining interest as alternatives to...
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