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Neurodegenerative Diseases

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PPAD: a deep learning architecture to predict progression of Alzheimer's disease.

Bioinformatics (Oxford, England)
MOTIVATION: Alzheimer's disease (AD) is a neurodegenerative disease that affects millions of people worldwide. Mild cognitive impairment (MCI) is an intermediary stage between cognitively normal state and AD. Not all people who have MCI convert to AD...

A Riemannian Deep Learning Representation to Describe Gait Parkinsonian Locomotor Patterns.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Parkinson is the second most common neurodegenerative disease, mainly related to progressive locomotor alterations caused by dopamine deficiency. The gait kinematic is a principal disease biomarker that associates patterns like the step length, flexe...

Predicting the Progression of Parkinson's Disease MDS-UPDRS-III Motor Severity Score from Gait Data using Deep Learning.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Parkinson's disease (PD) is a common neurodegenerative disease presenting with both motor and non-motor symptoms. Among PD motor symptoms, gait impairments are common and evolve over time. PD motor symptoms severity can be evaluated using clinical sc...

Robotic Systems Involved in the Diagnosis of Neurodegenerative Diseases.

Advances in experimental medicine and biology
The continuing development of robotics on the one hand and, on the other hand, the estimated relative growth in the number of elderly individuals suffering from neurodegenerative diseases raises the question of which contribution these powerful syste...

Using the structure of genome data in the design of deep neural networks for predicting amyotrophic lateral sclerosis from genotype.

Bioinformatics (Oxford, England)
MOTIVATION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by aberrations in the genome. While several disease-causing variants have been identified, a major part of heritability remains unexplained. ALS is believed to have...

The State of Nanorobotics in Medicine.

IEEE pulse
From ant-man to the Incredible Shrinking Machine, society has long envisioned developing devices tiny enough to enter human cells. Such nanotechnology could revolutionize the diagnosis of diseases like cancer and neurodegeneration, span new methods o...

Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment.

Bioinformatics (Oxford, England)
MOTIVATION: The concept of a 'mechanism-based taxonomy of human disease' is currently replacing the outdated paradigm of diseases classified by clinical appearance. We have tackled the paradigm of mechanism-based patient subgroup identification in th...

Gait assessment system based on novel gait variability measures.

IEEE ... International Conference on Rehabilitation Robotics : [proceedings]
In this paper, a novel gait assessment system based on measures of gait variability reflected through the variability of shapes of gait cycles trajectories is proposed. The presented gait assessment system is based on SVM (support vector machine) cla...

Role of Artificial Intelligence Techniques (Automatic Classifiers) in Molecular Imaging Modalities in Neurodegenerative Diseases.

Current Alzheimer research
Artificial Intelligence (AI) is a very active Computer Science research field aiming to develop systems that mimic human intelligence and is helpful in many human activities, including Medicine. In this review we presented some examples of the exploi...

Robotic psychophysics system for assessment, diagnosis and rehabilitation of the neurological causes of falls in the elderly.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Falls are the leading causes of unintentional injuries in the elderly and thus a pose a major hazard to our ageing society. We present the FOHEPO (FOot HEight POsitioning) system to measure, diagnose and eventually rehabilitate ageing-related neurolo...