AIMC Topic: Neurogenesis

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NeuriteNet: A convolutional neural network for assessing morphological parameters of neurite growth.

Journal of neuroscience methods Sep 2, 2021
BACKGROUND: During development or regeneration, neurons extend processes (i.e., neurites) via mechanisms that can be readily analyzed in culture. However, defining the impact of a drug or genetic manipulation on such mechanisms can be challenging due...
Mice Neurons Neurites Neurogenesis Neural Networks, Computer Animals
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Deep learning-based predictive identification of neural stem cell differentiation.

Nature communications May 10, 2021
The differentiation of neural stem cells (NSCs) into neurons is proposed to be critical in devising potential cell-based therapeutic strategies for central nervous system (CNS) diseases, however, the determination and prediction of differentiation is...
Microscopy, Electron, Transmission Neural Networks, Computer Fluorescent Antibody Technique Cells, Cultured Neurogenesis Computer Simulation Oligodendroglia Animals Astrocytes Deep Learning Neural Stem Cells Hormones Nanoparticles Neurons Rats Nerve Growth Factors
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A genome-wide multiphenotypic association analysis identified candidate genes and gene ontology shared by four common risky behaviors.

Aging Feb 22, 2020
BACKGROUND: Risky behaviors can lead to huge economic and health losses. However, limited efforts are paid to explore the genetic mechanisms of risky behaviors.
Humans Phenotype Autism Spectrum Disorder Risk-Taking Polymorphism, Single Nucleotide Transcriptome Intelligence Genome-Wide Association Study Gene Ontology Genetic Predisposition to Disease Neurogenesis
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Modeling of Brain-Like Concept Coding with Adulthood Neurogenesis in the Dentate Gyrus.

Computational intelligence and neuroscience Nov 3, 2019
Mammalian brains respond to new concepts via a type of neural coding termed "concept coding." During concept coding, the dentate gyrus (DG) plays a vital role in pattern separation and pattern integration of concepts because it is a brain region with...
Neuronal Plasticity Models, Neurological Action Potentials Neurons Concept Formation Neurogenesis Dentate Gyrus Association Humans Neural Networks, Computer Computer Simulation Animals
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Robotic platform for microinjection into single cells in brain tissue.

EMBO reports Aug 30, 2019
Microinjection into single cells in brain tissue is a powerful technique to study and manipulate neural stem cells. However, such microinjection requires expertise and is a low-throughput process. We developed the "Autoinjector", a robot that utilize...
Mice, Inbred C57BL Robotics Cell Communication Automation Single-Cell Analysis Image Processing, Computer-Assisted RNA, Messenger Telencephalon Cell Lineage Neurogenesis Microinjections Neural Stem Cells Humans Brain Animals
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DeTerm: Software for automatic detection of neuronal dendritic branch terminals via an artificial neural network.

Genes to cells : devoted to molecular & cellular mechanisms May 28, 2019
Dendrites of neurons receive and process synaptic or sensory inputs. The Drosophila class IV dendritic arborization (da) neuron is an established model system to explore molecular mechanisms of dendrite morphogenesis. The total number of dendritic br...
Drosophila Proteins Neurogenesis Drosophila Dendrites Purkinje Cells Larva Mice Neurons Cerebellum Neural Networks, Computer Software Animals
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Emergence of spontaneous assembly activity in developing neural networks without afferent input.

PLoS computational biology Sep 28, 2018
Spontaneous activity is a fundamental characteristic of the developing nervous system. Intriguingly, it often takes the form of multiple structured assemblies of neurons. Such assemblies can form even in the absence of afferent input, for instance in...
Male Neuronal Plasticity Models, Neurological Models, Statistical Neural Networks, Computer Neurogenesis Retina Software Sensory Receptor Cells Zebrafish Superior Colliculi Female Calcium Animals Stochastic Processes
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Design and validation of an ontology-driven animal-free testing strategy for developmental neurotoxicity testing.

Toxicology and applied pharmacology Mar 13, 2018
Developmental neurotoxicity entails one of the most complex areas in toxicology. Animal studies provide only limited information as to human relevance. A multitude of alternative models have been developed over the years, providing insights into mech...
Humans Animal Testing Alternatives Neurogenesis Cells, Cultured Neurotoxicity Syndromes Brain Reproducibility of Results Biological Ontologies Animals Toxicology Risk Assessment Models, Animal Signal Transduction Toxicity Tests Neurons
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Neural electrical activity and neural network growth.

Neural networks : the official journal of the International Neural Network Society Feb 9, 2018
The development of central and peripheral neural system depends in part on the emergence of the correct functional connectivity in its input and output pathways. Now it is generally accepted that molecular factors guide neurons to establish a primary...
Models, Neurological Neurons Neurogenesis Neural Networks, Computer
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A machine learning approach for the identification of key markers involved in brain development from single-cell transcriptomic data.

BMC genomics Dec 22, 2016
BACKGROUND: The ability to sequence the transcriptomes of single cells using single-cell RNA-seq sequencing technologies presents a shift in the scientific paradigm where scientists, now, are able to concurrently investigate the complex biology of a ...
Single-Cell Analysis Brain Machine Learning Support Vector Machine Reproducibility of Results Organ Specificity Algorithms Models, Statistical Gene Expression Profiling Neurogenesis Biomarkers Transcriptome Organogenesis
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