AIMC Topic: Neuroprotective Agents
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Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Dec 28, 2017
The use of essential oils (EOs) is known since long time in traditional medicine and aromatherapy for the management of various oxidative stress-related disorders and has been further increased recently for their neuroprotective and anti-aging potent...
Brain-inspired cheminformatics of drug-target brain interactome, synthesis, and assay of TVP1022 derivatives.
Neuropharmacology
Dec 23, 2015
The use of Cheminformatics tools is gaining importance in the field of translational research from Medicinal Chemistry to Neuropharmacology. In particular, we need it for the analysis of chemical information on large datasets of bioactive compounds. ...
Neuroprotective effects of the Phellinus linteus ethyl acetate extract against H2O2-induced apoptotic cell death of SK-N-MC cells.
Nutrition research (New York, N.Y.)
Nov 11, 2015
Numerous studies have suggested that neuronal cells are protected against oxidative stress-induced cell damage by antioxidants, such as polyphenolic compounds. Phellinus linteus (PL) has traditionally been used to treat various symptoms in East Asian...
MAP Kinase Signaling System
Basidiomycota
Fruiting Bodies, Fungal
Gene Expression Regulation, Enzymologic
Oxidoreductases
Acetates
Polysaccharides
Neurons
Solvents
Ethnopharmacology
Medicine, Korean Traditional
Phellinus
Cell Line, Tumor
Oxidative Stress
Antioxidants
Plant Extracts
Neuroprotective Agents
Apoptosis
Biological Products
Polyphenols
Nerve Tissue Proteins
Humans
Brain
Republic of Korea
Discovery, Biological Evaluation and Binding Mode Investigation of Novel Butyrylcholinesterase Inhibitors Through Hybrid Virtual Screening.
Molecules (Basel, Switzerland)
May 8, 2025
Butyrylcholinesterase (BChE), plays a critical role in alleviating the symptoms of Alzheimer's disease (AD) by regulating acetylcholine levels, emerging as an attractive target for AD treatment. This study employed a quantitative structure-activity r...
Optimizing Neuroprotective Nano-structured Lipid Carriers for Transdermal Delivery through Artificial Neural Network.
Pharmaceutical nanotechnology
Jan 1, 2025
BACKGROUND: Dementia associated with Alzheimer's disease (AD) is a neurological disorder. AD is a progressive neurodegenerative condition that predominantly impacts the elderly population, although it can also manifest in younger people through the i...
Add-on treatment with Cerebrolysin improves clinical symptoms in patients with ALS: results from a prospective, single-center, placebo-controlled, randomized, double-blind, phase II study.
Journal of medicine and life
Dec 1, 2023
Amyotrophic lateral sclerosis (ALS) is a devastating and progressive neurodegenerative disease with limited treatment options available. Cerebrolysin is a drug candidate for the treatment of ALS because of its neuroprotective and neuroregenerative ef...
Neuroprotective effects of Suhexiang Wan on the in vitro and in vivo models of Parkinson's disease.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
Dec 1, 2019
OBJECTIVE: To examine the role of KSOP1009 (a modified formulation of Suhexiang Wan essential oil) in an animal model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection.
Machine Learning-based Virtual Screening and Its Applications to Alzheimer's Drug Discovery: A Review.
Current pharmaceutical design
Jan 1, 2018
BACKGROUND: Virtual Screening (VS) has emerged as an important tool in the drug development process, as it conducts efficient in silico searches over millions of compounds, ultimately increasing yields of potential drug leads. As a subset of Artifici...
NEUROPROTECTIVE EFFECT OF BOSWELLIA SERRATA AND ITS ACTIVE CONSTITUENT ACETYL 11-KETO-β-BOSWELLIC ACID AGAINST OXYGEN-GLUCOSE-SERUM DEPRIVATION-INDUCED CELL INJURY.
Acta poloniae pharmaceutica
May 1, 2017
Oxidative stress plays a key role in pathophysiology of brain ischemia. This study aimed to test whether B. serrata hydroalcoholic extract (BSE) and its active constituent 3-acetyl-1 1-keto-β-boswellic acid (AKBA) could protect neurons against ischem...
Is levetiracetam neuroprotective in neonatal rats with hypoxic ischemic brain injury?
Bratislavske lekarske listy
Jan 1, 2016
BACKGROUND: The aim of this study was to determine if levetiracetam (LEV) is neuroprotective in neonatal rats with hypoxic-ischemic brain injury (HIBI).
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