AIMC Topic: Oligopeptides

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In silico identification of milk antihypertensive di- and tripeptides involved in angiotensin I-converting enzyme inhibitory activity.

Nutrition research (New York, N.Y.) Jul 28, 2017
Identification of bioactive milk peptides could improve food technology through improved selection of food supplements with a focus on antihypertensive properties. We hypothesized that angiotensin I-converting enzyme (ACE) inhibitory activities of mi...
Humans Animals Molecular Docking Simulation Cattle Peptide Fragments Dipeptides Hydrophobic and Hydrophilic Interactions Expert Systems Computational Biology Dietary Supplements Antihypertensive Agents Models, Molecular Proteolysis Binding Sites Milk Proteins Quantitative Structure-Activity Relationship Protein Conformation Hydrogen Bonding Peptidyl-Dipeptidase A Catalytic Domain Oligopeptides Angiotensin-Converting Enzyme Inhibitors
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and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes.

The Journal of biological chemistry May 23, 2017
Tumor exomes provide comprehensive information on mutated, overexpressed genes and aberrant splicing, which can be exploited for personalized cancer immunotherapy. Of particular interest are mutated tumor antigen T-cell epitopes, because neoepitope-s...
Mice, Transgenic Models, Immunological Protein Refolding T-Lymphocytes, Cytotoxic Mice, Knockout Peptide Fragments Epitopes HLA-A2 Antigen Protein Stability Expert Systems Oligopeptides Immunogenicity, Vaccine Antigens, Neoplasm Vaccines, Synthetic Membrane Proteins Neoplasm Proteins Animals Computational Biology Cancer Vaccines Humans Artificial Intelligence Cells, Cultured Melanoma Reproducibility of Results
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Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization.

International journal of nanomedicine Dec 30, 2016
Neovascularization (NV) of the cornea can disrupt visual function, causing ocular diseases, including blindness. Therefore, treatment of corneal NV has a high public health impact. Epigalloccatechin-3-gallate (EGCG), presenting antiangiogenesis effec...
Eye Burns Humans Mice, Inbred C57BL Ophthalmic Solutions Molecular Targeted Therapy Animals Hyaluronic Acid Cell Survival Oligopeptides Nanoparticles Catechin Burns, Chemical Integrin alphaVbeta3 Angiogenesis Inhibitors Human Umbilical Vein Endothelial Cells Corneal Neovascularization Disease Models, Animal
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Ultrasensitive Protease Sensors Using Selective Affinity Binding, Selective Proteolytic Reaction, and Proximity-Dependent Electrochemical Reaction.

Analytical chemistry Nov 30, 2016
The development of a fast and ultrasensitive protease detection method is a challenging task. This paper reports ultrasensitive protease sensors exploiting (i) selective affinity binding, (ii) selective proteolytic reaction, and (iii) proximity-depen...
Trypsin Proteolysis Aminophenols Graphite Immunoglobulin G Oligopeptides Oxidation-Reduction Electrochemical Techniques Tin Compounds Limit of Detection Oxides Electrodes
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Improved pan-specific prediction of MHC class I peptide binding using a novel receptor clustering data partitioning strategy.

HLA Oct 20, 2016
Pan-specific prediction of receptor-ligand interaction is conventionally done using machine-learning methods that integrates information about both receptor and ligand primary sequences. To achieve optimal performance using machine learning, dealing ...
Macaca Humans Gorilla gorilla Machine Learning Oligopeptides Pan troglodytes Epitopes Animals Protein Binding Alleles Mice Histocompatibility Antigens Class I Gene Expression Ligands Binding Sites Protein Interaction Domains and Motifs Structural Homology, Protein Software
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Feasibility of Deep Learning-Guided Attenuation and Scatter Correction of Whole-Body 68Ga-PSMA PET Studies in the Image Domain.

Clinical nuclear medicine Aug 1, 2021
OBJECTIVE: This study evaluates the feasibility of direct scatter and attenuation correction of whole-body 68Ga-PSMA PET images in the image domain using deep learning.
Humans Tomography, X-Ray Computed Male Deep Learning Oligopeptides Gallium Radioisotopes Image Processing, Computer-Assisted Scattering, Radiation Feasibility Studies Gallium Isotopes Positron-Emission Tomography Edetic Acid
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The retina revolution: signaling pathway therapies, genetic therapies, mitochondrial therapies, artificial intelligence.

Current opinion in ophthalmology May 1, 2020
PURPOSE OF REVIEW: The aim of this article is to review and discuss the history, current state, and future implications of promising biomedical offerings in the field of retina.
Vascular Endothelial Growth Factor A Oligopeptides Retinal Diseases Genetic Therapy Humans Artificial Intelligence Signal Transduction Angiogenesis Inhibitors Mitochondria
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AcSDKP is down-regulated in anaemia induced by infection in mice.

Malawi medical journal : the journal of Medical Association of Malawi Sep 1, 2017
BACKGROUND: Anaemia commonly results from destruction of erythrocytes in the peripheral blood and failure of the bone marrow haematopoietic cells to replenish the erythrocytes. The mechanisms involved in trypanosoma-induced anaemia, including the rol...
Hematocrit Interleukin-10 Trypanosoma brucei brucei Anemia Animals Trypanosomiasis, African Oligopeptides Mice Erythrocyte Count
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