AIMC Topic: Phosphatidylinositol 3-Kinases
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A risk prediction model of gene signatures in ovarian cancer through bagging of GA-XGBoost models.
Journal of advanced research
Nov 11, 2020
INTRODUCTION: Ovarian cancer (OC) is one of the most frequent gynecologic cancers among women, and high-accuracy risk prediction techniques are essential to effectively select the best intervention strategies and clinical management for OC patients a...
A comparison of machine learning classifiers for dementia with Lewy bodies using miRNA expression data.
BMC medical genomics
Oct 30, 2019
BACKGROUND: Dementia with Lewy bodies (DLB) is the second most common subtype of neurodegenerative dementia in humans following Alzheimer's disease (AD). Present clinical diagnosis of DLB has high specificity and low sensitivity and finding potential...
Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival.
Journal of the American Heart Association
Oct 16, 2019
Background Small molecule kinase inhibitors (KIs) are a class of agents currently used for treatment of various cancers. Unfortunately, treatment of cancer patients with some of the KIs is associated with cardiotoxicity, and there is an unmet need fo...
Assessment of Functional Phosphatidylinositol 3-Kinase Pathway Activity in Cancer Tissue Using Forkhead Box-O Target Gene Expression in a Knowledge-Based Computational Model.
The American journal of pathology
Jul 6, 2018
The phosphatidylinositol 3-kinase (PI3K) pathway is commonly activated in cancer. Tumors are potentially sensitive to PI3K pathway inhibitors, but reliable diagnostic tests that assess functional PI3K activity are lacking. Because PI3K pathway activi...
Leptin Stimulates Prolactin mRNA Expression in the Goldfish Pituitary through a Combination of the PI3K/Akt/mTOR, MKK/pMAPK and MEK/ERK Signalling Pathways.
International journal of molecular sciences
Dec 20, 2017
Leptin actions at the pituitary level have been extensively investigated in mammalian species, but remain insufficiently characterized in lower vertebrates, especially in teleost fish. Prolactin (PRL) is a pituitary hormone of central importance to o...
Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Dec 11, 2017
Ginsenoside Rg1, one of the most notable active components of Panax ginseng, has been widely reported to exert anti-inflammatory actions. This study aimed to reveal whether ginsenoside Rg1 also exhibits beneficial roles against lipopolysaccharide (LP...
Kidney Tubules
Cell Migration Assays
Reproducibility of Results
Ginsenosides
Enzyme-Linked Immunosorbent Assay
Nephritis
Apoptosis
Lipopolysaccharides
Cell Line
Blotting, Western
Reactive Oxygen Species
Humans
Anti-Inflammatory Agents
Epithelial Cells
Cytokines
Phosphatidylinositol 3-Kinases
Cell Survival
Proto-Oncogene Proteins c-akt
Protective Agents
Analysis of Variance
Computer-aided unveiling molecular mechanisms of Xylocarpus granatum against colorectal cancer: therapeutic intervention targeting P13K-AKT signaling pathway.
Computers in biology and medicine
Jul 1, 2025
Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality globally, with increasing incidence rates, particularly in early-onset cases. Despite advances in treatment, many developing countries face affordability and safety ...
Protein Profiles Predict Treatment Responses to the PI3K Inhibitor Umbralisib in Patients with Chronic Lymphocytic Leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research
May 15, 2025
PURPOSE: The management of chronic lymphocytic leukemia (CLL) has significantly improved with targeted therapies. However, many patients experience a suboptimal response. To optimally select the best therapy, predictive biomarkers are necessary. In t...
Phosphatidylinositol 3-Kinases
Humans
Protein Kinase Inhibitors
Agammaglobulinaemia Tyrosine Kinase
Female
Benzamides
Aged
Phosphoinositide-3 Kinase Inhibitors
Middle Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Treatment Outcome
Leukemia, Lymphocytic, Chronic, B-Cell
Pyrazines
Male
Unveiling the Immune Landscape of Delirium through Single-Cell RNA Sequencing and Machine Learning: Towards Precision Diagnosis and Therapy.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
Jan 1, 2025
BACKGROUND: Postoperative delirium (POD) poses significant clinical challenges regarding its diagnosis and treatment. Identifying biomarkers that can predict and diagnose POD is crucial for improving patient outcomes.
[Experimental study of APB-DOCK8 transgenic tomato vaccine for caries prevention].
Shanghai kou qiang yi xue = Shanghai journal of stomatology
Dec 1, 2023
PURPOSE: To observe the anti-caries effect of transgenic tomato anti-caries vaccine after immunization with SD rats by gavage and to explore its immunity mechanism initially.
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