AIMC Topic: Precision Medicine

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Tensor Factorization for Precision Medicine in Heart Failure with Preserved Ejection Fraction.

Journal of cardiovascular translational research
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical syndrome that may benefit from improved subtyping in order to better characterize its pathophysiology and to develop novel targeted therapies. The United States Precis...

PCM-SABRE: a platform for benchmarking and comparing outcome prediction methods in precision cancer medicine.

BMC bioinformatics
BACKGROUND: Numerous publications attempt to predict cancer survival outcome from gene expression data using machine-learning methods. A direct comparison of these works is challenging for the following reasons: (1) inconsistent measures used to eval...

Patient-Centered Robot-Aided Passive Neurorehabilitation Exercise Based on Safety-Motion Decision-Making Mechanism.

BioMed research international
Safety is one of the crucial issues for robot-aided neurorehabilitation exercise. When it comes to the passive rehabilitation training for stroke patients, the existing control strategies are usually just based on position control to carry out the tr...

Artificial intelligence in medicine.

Metabolism: clinical and experimental
Artificial Intelligence (AI) is a general term that implies the use of a computer to model intelligent behavior with minimal human intervention. AI is generally accepted as having started with the invention of robots. The term derives from the Czech ...

Construction of longitudinal prediction targets using semisupervised learning.

Statistical methods in medical research
In establishing prognostic models, often aided by machine learning methods, much effort is concentrated in identifying good predictors. However, the same level of rigor is often absent in improving the outcome side of the models. In this study, we fo...

Biologically Relevant Heterogeneity: Metrics and Practical Insights.

SLAS discovery : advancing life sciences R & D
Heterogeneity is a fundamental property of biological systems at all scales that must be addressed in a wide range of biomedical applications, including basic biomedical research, drug discovery, diagnostics, and the implementation of precision medic...

The Human Phenotype Ontology in 2017.

Nucleic acids research
Deep phenotyping has been defined as the precise and comprehensive analysis of phenotypic abnormalities in which the individual components of the phenotype are observed and described. The three components of the Human Phenotype Ontology (HPO; www.hum...

A support vector machine model provides an accurate transcript-level-based diagnostic for major depressive disorder.

Translational psychiatry
Major depressive disorder (MDD) is a critical cause of morbidity and disability with an economic cost of hundreds of billions of dollars each year, necessitating more effective treatment strategies and novel approaches to translational research. A no...

A Realistic Seizure Prediction Study Based on Multiclass SVM.

International journal of neural systems
A patient-specific algorithm, for epileptic seizure prediction, based on multiclass support-vector machines (SVM) and using multi-channel high-dimensional feature sets, is presented. The feature sets, combined with multiclass classification and post-...